NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE52584 Query DataSets for GSE52584
Status Public on Nov 22, 2013
Title Gene and microRNA transcriptome analysis of Parkinson's related LRRK2 mouse models
Platform organisms Mus musculus; synthetic construct
Sample organism Mus musculus
Experiment type Expression profiling by array
Non-coding RNA profiling by array
Summary Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of familial and sporadic Parkinson’s disease (PD). Here, we investigated in parallel gene and microRNA transcriptome profiles of three different LRRK2 mouse models. Striatal tissue was isolated from adult LRRK2 knockout mice, as well as mice expressinghuman LRRK2 wildtype (hLRRK2-WT) or PD-associated R1441G mutation (hLRRK2-R1441G).
 
Overall design We used microarraya to measure gene and microRNA expression levels in various LRRK2 mouse models.
LRRK2 wildtype and knockout mice were bred on a C57BL/6 background. LRRK2 non-transgenic and hLRRK2 transgenic mice were bred on a FVB/N background.
 
Contributor(s) Dorval V, Hebert SS
Citation(s) 24427314
Submission date Nov 20, 2013
Last update date Mar 04, 2019
Contact name Sebastien Hebert
E-mail(s) [email protected]
Organization name Lavay University
Department Medecine
Street address 2705 Boul Laurier, Centre de recherche du CHU de Quebec
City Quebec
State/province QC
ZIP/Postal code G1V4G2
Country Canada
 
Platforms (3)
GPL6246 [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]
GPL8786 [miRNA-1] Affymetrix Multispecies miRNA-1 Array
GPL14613 [miRNA-2] Affymetrix Multispecies miRNA-2 Array
Samples (40)
GSM1272462 LRRK2-4mo-Striatum-KO-A-(MoGene-1.0-st-v1)
GSM1272463 LRRK2-4mo-Striatum-KO-B-(MoGene-1.0-st-v1)
GSM1272464 LRRK2-4mo-Striatum-KO-C-(MoGene-1.0-st-v1)
Relations
BioProject PRJNA229469

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE52584_RAW.tar 96.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap