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| Status |
Public on Jun 01, 2007 |
| Title |
Transcript profiles of DCs of PLOSL patients show abnormalities in pathways of actin bundling and immune response |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
This study was aimed to identify pathways associated with loss-of-function of the DAP12/TREM2 receptor complex and thus gain insight into pathogenesis of PLOSL (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy). Transcript profiles of PLOSL patients' DCs showed differential expression of genes involved in actin bundling and immune response, but also for the stability of myelin and bone remodeling.
Keywords: PLOSL patient samples vs. control samples
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| Overall design |
Transcript profiles of in vitro differentiated DCs of three controls and five PLOSL patients were analyzed.
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| Contributor(s) |
Kiialainen A, Veckman V, Saharinen J, Paloneva J, Gentile M, Hakola P, Hemelsoet D, Ridha B, Kopra O, Julkunen I, Peltonen L |
| Citation(s) |
17530208 |
| |
| Submission date |
Nov 17, 2005 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Anna Kiialainen |
| E-mail(s) |
[email protected]
|
| Phone |
+46186114951
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| Organization name |
Uppsala University
|
| Department |
Deapartment of Medical Sciences
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| Street address |
University Hospital, Entrance 70
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| City |
Uppsala |
| ZIP/Postal code |
75185 |
| Country |
Sweden |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA93729 |
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