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    hts hu li tai shao [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37230, updated on 9-Dec-2024

    Summary

    Official Symbol
    htsprovided by FlyBase
    Official Full Name
    hu li tai shaoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263391
    Locus tag
    Dmel_CG43443
    See related
    AllianceGenome:FB:FBgn0263391
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1B1; add; Add; ADD-87; Add-hts; add-like; Add1; Add2; adducin; Adducin; anon-EST:Posey9; CG34197; CG43443; CG9325; Dmel\CG43443; EST D; Hts; HTS; HTS-R1; Hts-RC; HTS-RC; HtsF; htsRC; HtsRC; HTS_DROME; l(2)00634; l(2)01103; l(2)k06121; l(2)k14523; Ovhts; Ovhts-RC; sxp
    Old locus tag
    Dmel_CG34197; Dmel_CG9325
    Summary
    Predicted to enable actin filament binding activity. Involved in several processes, including adult somatic muscle development; cytoskeleton organization; and fusome organization. Located in several cellular components, including fusome; germline ring canal; and spectrosome. Is active in postsynapse and presynapse. Colocalizes with actin filament. Is expressed in several structures, including epithelium; fusome; germline cell; gonad; and somatic cell of ovariole. Used to study cerebral palsy and spastic quadriplegic cerebral palsy 3. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; gastroschisis; and spastic quadriplegic cerebral palsy 3. Orthologous to human ADD1 (adducin 1); ADD2 (adducin 2); and ADD3 (adducin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See hts in Genome Data Viewer
    Location:
    56D3-56D5; 2-89 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19397032..19424903, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15284537..15312408, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45925 Neighboring gene Succinate dehydrogenase, subunit A (flavoprotein) Neighboring gene antisense RNA:CR43430 Neighboring gene crammer Neighboring gene transfer RNA:Serine-CGA 1-4 Neighboring gene transfer RNA:Valine-AAC 2-1 Neighboring gene transfer RNA:Valine-AAC 2-2 Neighboring gene ncRNA Neighboring gene Calpain-A Neighboring gene Focal adhesion kinase

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding  
    Process Evidence Code Pubs
    involved_in actin filament bundle organization PubMed 
    involved_in adult somatic muscle development PubMed 
    involved_in axon guidance PubMed 
    involved_in centrosome cycle PubMed 
    involved_in cystoblast division PubMed 
    involved_in female germ-line cyst formation PubMed 
    involved_in female germline ring canal formation, actin assembly PubMed 
    involved_in female germline ring canal formation, actin assembly PubMed 
    involved_in fusome organization PubMed 
    involved_in germ-line cyst formation PubMed 
    involved_in germarium-derived oocyte fate determination PubMed 
    involved_in meiotic spindle organization PubMed 
    involved_in oogenesis PubMed 
    involved_in ovarian fusome organization PubMed 
    involved_in photoreceptor cell axon guidance PubMed 
    involved_in photoreceptor cell axon guidance PubMed 
    involved_in photoreceptor cell axon guidance PubMed 
    involved_in postsynapse organization PubMed 
    involved_in sarcomere organization PubMed 
    involved_in testicular fusome organization PubMed 
    Component Evidence Code Pubs
    colocalizes_with actin filament PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    is_active_in cytoskeleton  
    located_in female germline ring canal inner rim PubMed 
    located_in fusome PubMed 
    located_in fusome PubMed 
    located_in germline ring canal PubMed 
    located_in germline ring canal PubMed 
    located_in lateral plasma membrane PubMed 
    located_in plasma membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    is_active_in postsynapse PubMed 
    is_active_in postsynaptic density  
    is_active_in presynapse PubMed 
    located_in spectrosome PubMed 

    General protein information

    Preferred Names
    hu li tai shao
    Names
    Adducin-like 56D
    Adducin-like-56D
    CG43443-PA
    CG43443-PC
    CG43443-PD
    CG43443-PH
    CG43443-PI
    CG43443-PJ
    CG43443-PK
    CG43443-PL
    CG43443-PM
    CG43443-PN
    CG43443-PO
    CG43443-PP
    CG43443-PQ
    CG43443-PR
    CG43443-PS
    CG43443-PT
    Hu Li Tai shao
    Hu li-tai shao
    Hu-li tai shao
    Hu-li tai-shao
    adducin
    adducin-like
    hts-PA
    hts-PC
    hts-PD
    hts-PH
    hts-PI
    hts-PJ
    hts-PK
    hts-PL
    hts-PM
    hts-PN
    hts-PO
    hts-PP
    hts-PQ
    hts-PR
    hts-PS
    hts-PT
    hu-li tai shao protein
    hu-li-tai-shao
    ovarian hu-li tai shao-ring canal protein
    NP_725886.2
    • unusual splice
    NP_725887.2
    • unusual splice
    NP_725888.2
    • unusual splice

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19397032..19424903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202048.3 → NP_001188977.2  hu li tai shao, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188977.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7A5
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    2. NM_001259491.2 → NP_001246420.1  hu li tai shao, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246420.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K849
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    3. NM_001299683.1 → NP_001286612.1  hu li tai shao, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K849
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    4. NM_001259492.2 → NP_001246421.1  hu li tai shao, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246421.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7A5
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    5. NM_166348.3 → NP_725887.2  hu li tai shao, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725887.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02645
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    6. NM_166349.3 → NP_725888.2  hu li tai shao, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725888.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02645
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    7. NM_166347.3 → NP_725886.2  hu li tai shao, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725886.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02645
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    8. NM_057529.4 → NP_476877.1  hu li tai shao, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476877.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZBK8, A4UZP6, E1JGM4, E1JGM6, Q02645, Q8MQX6, Q9GNA8, Q9GZC1, Q9V8U4, Q9V8U5
      Related
      FBpp0301112
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    9. NM_001169734.2 → NP_001163205.1  hu li tai shao, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163205.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZBK8, A4UZP6, E1JGM4, E1JGM6, Q02645, Q8MQX6, Q9GNA8, Q9GZC1, Q9V8U4, Q9V8U5
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    10. NM_001169735.2 → NP_001163206.1  hu li tai shao, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163206.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZBK8, A4UZP6, E1JGM4, E1JGM6, Q02645, Q8MQX6, Q9GNA8, Q9GZC1, Q9V8U4, Q9V8U5
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    11. NM_001103907.3 → NP_001097377.2  hu li tai shao, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097377.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYJ2
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    12. NM_166350.2 → NP_725889.1  hu li tai shao, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725889.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02645
      Related
      FBpp0301110
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    13. NM_001382109.1 → NP_001369098.1  hu li tai shao, isoform T [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q7Q7
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    14. NM_166351.2 → NP_725890.1  hu li tai shao, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725890.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02645
      Related
      FBpp0301111
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    15. NM_001169732.2 → NP_001163203.1  hu li tai shao, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163203.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02645
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    16. NM_001169733.2 → NP_001163204.1  hu li tai shao, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163204.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q02645
      Conserved Domains (1) summary
      cd00398
      Location:116 → 323
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
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