Gcn5 Gcn5 acetyltransferase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gcn5provided by FlyBase
Official Full Name: Gcn5 acetyltransferaseprovided by FlyBase
Primary source: FLYBASE:FBgn0020388
Locus tag: Dmel_CG4107
See related: AllianceGenome:FB:FBgn0020388
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Ada4; anon-WO0172774.89; CG4107; dGcn5; dGCN5; dGCN5 HAT; dGcn5i; dKAT2; Dmel\CG4107; dmGCN5; dmHAG401; dPCAF; gcn5; GCN5; Gcn5/Pcaf; Gcn5/PCAF; KAT; KAT2; p/CAF; P/CAF; pCAF; Pcaf; PCAF
Summary: Enables chromatin binding activity; histone H3 acetyltransferase activity; and histone H4 acetyltransferase activity. Involved in chromatin remodeling. Located in nucleus and polytene chromosome puff. Part of ATAC complex; H3 histone acetyltransferase complex; and SAGA complex. Is expressed in several structures, including CNS glial cell; antennal anlage; embryonic/larval midgut primordium; ganglia; and mesoderm. Used to study heart disease and kidney disease. Orthologous to several human genes including KAT2A (lysine acetyltransferase 2A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 69C4-69C4; 3-38 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (12521129..12524014, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (12514229..12517114, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5.
Title: DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5.
Quantitative Acetylomics Reveals Substrates of Lysine Acetyltransferase GCN5 in Adult and Aging Drosophila.
Title: Quantitative Acetylomics Reveals Substrates of Lysine Acetyltransferase GCN5 in Adult and Aging Drosophila.
CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity.
Title: CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity.
Drosophila USP22/nonstop polarizes the actin cytoskeleton during collective border cell migration.
Title: Drosophila USP22/nonstop polarizes the actin cytoskeleton during collective border cell migration.
Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB.
Title: Acetyltransferase GCN5 regulates autophagy and lysosome biogenesis by targeting TFEB.
The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability.
Title: The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability.
that Gcn5 is dispensable for the transcriptional silencing of bam, but interacts with Cyclin A to facilitate proper turnover in germline stem cells
Title: Gcn5 determines the fate of Drosophila germline stem cells through degradation of Cyclin A.
Results support the model that CP190 recruits Gcn5 and thereby activates chromatin.
Title: Chromatin binding of Gcn5 in Drosophila is largely mediated by CP190.
The C-terminal domains of ADA2 proteins determine selective incorporation into GCN5-containing complexes that target histone H3 or H4 for acetylation.
Title: The C-terminal domains of ADA2 proteins determine selective incorporation into GCN5-containing complexes that target histone H3 or H4 for acetylation.
partial loss of Pcaf significantly enhanced polyglutamine pathologyin a Drosophila model of Huntington's disease
Title: Pcaf modulates polyglutamine pathology in a Drosophila model of Huntington's disease.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H3 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ATAC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of H3 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome puff	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Gcn5 acetyltransferase

Names: CG4107-PA; Gcn5 ortholog; Gcn5-PA; pcaf

NP_648586.2

EC 2.3.1.-

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

12521129..12524014 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140329.3 → NP_648586.2 Gcn5 acetyltransferase [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648586.2

Status: REVIEWED

UniProtKB/TrEMBL

O76216, Q9VTZ1

Related

FBpp0075701

Conserved Domains (4) summary

cd05509
Location:708 → 808

Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...

COG5076
Location:451 → 807

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

pfam00583
Location:526 → 598

Acetyltransf_1; Acetyltransferase (GNAT) family

pfam06466
Location:73 → 322

PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain