U.S. flag

An official website of the United States government

Links from Nucleotide

    • Showing Current items.

    AspRS Aspartyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36420, updated on 9-Dec-2024

    Summary

    Official Symbol
    AspRSprovided by FlyBase
    Official Full Name
    Aspartyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002069
    Locus tag
    Dmel_CG3821
    See related
    AllianceGenome:FB:FBgn0002069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    aaRS(Asp); aats-asp; Aats-asp; Aats-Asp; anon-EST:Liang-2.49; cDNA1; CG3821; clone 2.49; DARS; Dmel\CG3821; DRS; l(2)49Db; l(2)k04508; l(2)v27; l(2)vr1; poney; vr1
    Summary
    Predicted to enable RNA binding activity and aspartate-tRNA ligase activity. Predicted to be involved in aspartyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in adult head; adult heart; embryonic/larval salivary gland; and organism. Orthologous to human DARS1 (aspartyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AspRS in Genome Data Viewer
    Location:
    49D6-49D7; 2-67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12877004..12883168)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8764509..8770673)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43469 Neighboring gene antisense RNA:CR43468 Neighboring gene Beta-alanine transporter Neighboring gene Lifeguard Neighboring gene N-methyl-D-aspartate receptor-associated protein Neighboring gene antisense RNA:CR45141 Neighboring gene vestigial Neighboring gene long non-coding RNA:CR46237

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables RNA binding  
    enables aspartate-tRNA ligase activity  
    enables aspartate-tRNA ligase activity  
    enables aspartate-tRNA ligase activity PubMed 
    enables nucleic acid binding  
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex  
    part_of aminoacyl-tRNA synthetase multienzyme complex PubMed 
    located_in cytoplasm  
    located_in cytoplasm PubMed 
    is_active_in cytosol  

    General protein information

    Preferred Names
    Aspartyl-tRNA synthetase
    Names
    AspRS-PA
    AspRS-PB
    AspRS-PC
    CG3821-PA
    CG3821-PB
    CG3821-PC
    lethal(2)49Db
    NP_001260930.1
    NP_001260931.1
    NP_476609.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12877004..12883168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274002.2 → NP_001260931.1  Aspartyl-tRNA synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260931.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0E6, Q9XYM1
      Conserved Domains (3) summary
      PLN02850
      Location:49 → 531
      PLN02850; aspartate-tRNA ligase
      cd00776
      Location:203 → 527
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04320
      Location:89 → 187
      AspRS_cyto_N; AspRS_cyto_N: N-terminal, anticodon recognition domain of the type found in Saccharomyces cerevisiae and human cytoplasmic aspartyl-tRNA synthetase (AspRS). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...
    2. NM_057261.4 → NP_476609.1  Aspartyl-tRNA synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0E6, Q9XYM1
      Related
      FBpp0086897
      Conserved Domains (3) summary
      PLN02850
      Location:49 → 531
      PLN02850; aspartate-tRNA ligase
      cd00776
      Location:203 → 527
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04320
      Location:89 → 187
      AspRS_cyto_N; AspRS_cyto_N: N-terminal, anticodon recognition domain of the type found in Saccharomyces cerevisiae and human cytoplasmic aspartyl-tRNA synthetase (AspRS). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...
    3. NM_001274001.1 → NP_001260930.1  Aspartyl-tRNA synthetase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K0E6, Q9XYM1
      Conserved Domains (3) summary
      PLN02850
      Location:49 → 531
      PLN02850; aspartate-tRNA ligase
      cd00776
      Location:203 → 527
      AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
      cd04320
      Location:89 → 187
      AspRS_cyto_N; AspRS_cyto_N: N-terminal, anticodon recognition domain of the type found in Saccharomyces cerevisiae and human cytoplasmic aspartyl-tRNA synthetase (AspRS). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. ...
    External link. Please review our privacy policy.