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GlnRS Glutaminyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45786, updated on 9-Dec-2024

Summary

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Official Symbol
GlnRSprovided by FlyBase
Official Full Name
Glutaminyl-tRNA synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0027090
Locus tag
Dmel_CG10506
See related
AllianceGenome:FB:FBgn0027090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Aast-g1n; Aats-gln; BcDNA:GH11673; CG10506; Dmel\CG10506; dQARS; l(3)05461; qars; QRS
Summary
Predicted to enable glutamine-tRNA ligase activity. Involved in dendrite morphogenesis. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in adult head and organism. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See GlnRS in Genome Data Viewer
Location:
96C8-96C8; 3-87 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25263267..25265721, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21088989..21091443, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46099 Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45214 Neighboring gene RIO kinase 2 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals. Kerjan P, et al. Biochim Biophys Acta, 1994 Apr 21. PMID 8161568
  2. Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization. Chihara T, et al. Nat Neurosci, 2007 Jul. PMID 17529987
  3. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
  4. Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis. Yeom E, et al. Front Cell Dev Biol, 2020. PMID 32117966, Free PMC Article
  5. MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure. Wu Z, et al. Mol Cell, 2019 Aug 22. PMID 31378462, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glutamine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamine-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glutaminyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutaminyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in glutaminyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Glutaminyl-tRNA synthetase
Names
CG10506-PA
GlnRS-PA
NP_524841.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25263267..25265721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080102.5 → NP_524841.1  Glutaminyl-tRNA synthetase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524841.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VBU3, Q9Y105
    Related
    FBpp0084240
    Conserved Domains (1) summary
    PLN02859
    Location:10 → 777
    PLN02859; glutamine-tRNA ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y105.1 Q9Y105

Gene LinkOut

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