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GluProRS Glutamyl-prolyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42834, updated on 9-Dec-2024

Summary

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Official Symbol
GluProRSprovided by FlyBase
Official Full Name
Glutamyl-prolyl-tRNA synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0005674
Locus tag
Dmel_CG5394
See related
AllianceGenome:FB:FBgn0005674
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Aa-tRNA-syn-glupro; AATS; Aats-glu; Aats-glupro; AATs-GluPro; CG5394; Dmel\CG5394; EPRS; ERS; FBpp0083898; Glu-ProRS; GluPro-RS; GluRS; glutamyl-prolyl-tRNA synthetase; p200
Summary
Enables glutamate-tRNA ligase activity and proline-tRNA ligase activity. Involved in glutamyl-tRNA aminoacylation and prolyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 15. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See GluProRS in Genome Data Viewer
Location:
95D1-95D1; 3-82 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23952136..23958391, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19777858..19784113, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Glutamate dehydrogenase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46092 Neighboring gene Adaptor Protein complex 1, sigma subunit Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DoMosaics: software for domain arrangement visualization and domain-centric analysis of proteins. Moore AD, et al. Bioinformatics, 2014 Jan 15. PMID 24222210
  2. A gene fusion event in the evolution of aminoacyl-tRNA synthetases. Berthonneau E, et al. FEBS Lett, 2000 Mar 31. PMID 10745085
  3. Evolution of the aminoacyl-tRNA synthetase family and the organization of the Drosophila glutamyl-prolyl-tRNA synthetase gene. Intron/exon structure of the gene, control of expression of the two mRNAs, selective advantage of the multienzyme complex. Cerini C, et al. Eur J Biochem, 1997 Feb 15. PMID 9063462
  4. A component of the multisynthetase complex is a multifunctional aminoacyl-tRNA synthetase. Cerini C, et al. EMBO J, 1991 Dec. PMID 1756734, Free PMC Article
  5. SUMOylation of Arginyl tRNA Synthetase Modulates the Drosophila Innate Immune Response. Nayak P, et al. Front Cell Dev Biol, 2021. PMID 34660574, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glutamate-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables proline-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proline-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables proline-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables proline-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutamyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glutamyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in prolyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prolyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in prolyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in prolyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Glutamyl-prolyl-tRNA synthetase
Names
CG5394-PA
CG5394-PB
GluProRS-PA
GluProRS-PB
Glutamyl-tRNA synthetase
aminoacyl-tRNA synthetase
bifunctional aminoacyl-tRNA synthetase
glutamyl-prolyl-tRA synthetase
transfer RNA-Glu-Pro aminoacyl synthetase
NP_524471.2
NP_732925.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    23952136..23958391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079747.3 → NP_524471.2  Glutamyl-prolyl-tRNA synthetase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524471.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P28668, Q8IGR4, Q8IMX9, Q95TL3, Q9VCF5
    Related
    FBpp0083898
    Conserved Domains (9) summary
    cd10309
    Location:76 → 153
    GST_C_GluProRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of bifunctional Glutamyl-Prolyl-tRNA synthetase
    PLN02907
    Location:1 → 715
    PLN02907; glutamate-tRNA ligase
    PRK08661
    Location:1220 → 1714
    PRK08661; prolyl-tRNA synthetase; Provisional
    cd00778
    Location:1224 → 1486
    ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cd00862
    Location:1492 → 1714
    ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
    cd00936
    Location:973 → 1022
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
    pfam00458
    Location:748 → 799
    WHEP-TRS; WHEP-TRS domain
    pfam00749
    Location:203 → 508
    tRNA-synt_1c; tRNA synthetases class I (E and Q), catalytic domain
    pfam03950
    Location:510 → 688
    tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain

  2. NM_170103.2 → NP_732925.1  Glutamyl-prolyl-tRNA synthetase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732925.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H8F4R5
    Related
    FBpp0083899
    Conserved Domains (5) summary
    PRK08661
    Location:502 → 996
    PRK08661; prolyl-tRNA synthetase; Provisional
    cd00778
    Location:506 → 768
    ProRS_core_arch_euk; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cd00862
    Location:774 → 996
    ProRS_anticodon_zinc; ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in ...
    cd00936
    Location:30 → 79
    WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...
    pfam00458
    Location:176 → 227
    WHEP-TRS; WHEP-TRS domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28668.2 P28668

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