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MRP Multidrug-Resistance like Protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34686, updated on 9-Dec-2024

Summary

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Official Symbol
MRPprovided by FlyBase
Official Full Name
Multidrug-Resistance like Protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0032456
Locus tag
Dmel_CG6214
See related
AllianceGenome:FB:FBgn0032456
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ABCC1; CG6214; DmCG6214; Dmel\CG6214; dmrp; dMRP; dMRP/CG6214; dMRP1; lincRNA.123; Mrp; Mrp1; MRP1
Summary
Enables ATPase-coupled inorganic anion transmembrane transporter activity. Involved in monoatomic anion transmembrane transport; renal tubular secretion; and response to toxic substance. Located in plasma membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in several diseases, including bile duct disease (multiple); bilirubin metabolic disorder (multiple); leukemia (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including ABCC1 (ATP binding cassette subfamily C member 1 (ABCC1 blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See MRP in Genome Data Viewer
Location:
33F3-33F5; 2-47 cM
Exon count:
22
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12719045..12766546)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12719045..12744807)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PIH1 domain containing 1 Neighboring gene mir-9382 stem loop Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46206 Neighboring gene long noncoding RNA: testis-specific 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Target organ specific activity of drosophila MRP (ABCC1) moderates developmental toxicity of methylmercury. Prince L, et al. Toxicol Sci, 2014 Aug 1. PMID 24863968, Free PMC Article
  2. Convergent intron loss of MRP1 in Drosophila and mosquito species. Zhan LL, et al. J Hered, 2012 Jan-Feb. PMID 21908794
  3. The high turnover Drosophila multidrug resistance-associated protein shares the biochemical features of its human orthologues. Szeri F, et al. Biochim Biophys Acta, 2009 Feb. PMID 19059376
  4. In vitro transport of methotrexate by Drosophila Multidrug Resistance-associated Protein. Karasik A, et al. PLoS One, 2018. PMID 30312334, Free PMC Article
  5. Boosted coupling of ATP hydrolysis to substrate transport upon cooperative estradiol-17-β-D-glucuronide binding in a Drosophila ATP binding cassette type-C transporter. Karasik A, et al. FASEB J, 2018 Feb. PMID 28939593, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the second E2G binding-similar to human ABCC2-allosterically stimulates transport activity of DMRP.
    Title: Boosted coupling of ATP hydrolysis to substrate transport upon cooperative estradiol-17-β-D-glucuronide binding in a Drosophila ATP binding cassette type-C transporter.
  2. dMRP and MET are not the dominant methotrexate (MTX) transporters in the tubules when flies are reared on MTX-enriched diets.
    Title: Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules of Drosophila melanogaster.
  3. DMRP is capable of transporting a known MRP1 substrate and is a high capacity ATP-dependent, vanadate-sensitive organic anion transporter.
    Title: The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 12731125-12735818 mobile_element_type = transposon:F{}349
  • Loc: 12763895-12764039 mobile_element_type = transposon:BS{}351

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled inorganic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic anion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in renal tubular secretion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Multidrug-Resistance like protein 1
Names
CG6214-PA
CG6214-PB
CG6214-PC
CG6214-PD
CG6214-PE
CG6214-PF
CG6214-PG
CG6214-PH
CG6214-PI
CG6214-PJ
CG6214-PK
CG6214-PL
CG6214-PM
CG6214-PN
CG6214-PO
CG6214-PP
CG6214-PQ
CG6214-PR
MRP-PA
MRP-PB
MRP-PC
MRP-PD
MRP-PE
MRP-PF
MRP-PG
MRP-PH
MRP-PI
MRP-PJ
MRP-PK
MRP-PL
MRP-PM
MRP-PN
MRP-PO
MRP-PP
MRP-PQ
MRP-PR
Multidrug-resistance protein
multidrug resistance like protein
multidrug resistance-associated protein
multidrug resistance-like protein
multidrug resistance-like protein 1
NP_001303319.1
NP_609591.2
NP_723772.2
NP_995690.1
NP_995691.1
NP_995692.1
NP_995693.1
NP_995694.1
NP_995695.1
NP_995696.1
NP_995697.1
NP_995698.1
NP_995699.1
NP_995700.1
NP_995701.1
NP_995702.1
NP_995703.1
NP_995704.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12719045..12766546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316390.1 → NP_001303319.1  Multidrug-Resistance like protein 1, isoform R [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0WIA2, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1485
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1491
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 605
    ABC_membrane; ABC transporter transmembrane region

  2. NM_205977.2 → NP_995699.1  Multidrug-Resistance like protein 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995699.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTC7, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 601
    ABC_membrane; ABC transporter transmembrane region

  3. NM_205980.2 → NP_995702.1  Multidrug-Resistance like protein 1, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995702.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9C5, Q9VK56
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1548
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1308 → 1528
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 601
    ABC_membrane; ABC transporter transmembrane region

  4. NM_205973.2 → NP_995695.1  Multidrug-Resistance like protein 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995695.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTC6, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 601
    ABC_membrane; ABC transporter transmembrane region

  5. NM_205979.2 → NP_995701.1  Multidrug-Resistance like protein 1, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995701.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTC5, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 601
    ABC_membrane; ABC transporter transmembrane region

  6. NM_205970.2 → NP_995692.1  Multidrug-Resistance like protein 1, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995692.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTC3, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 605
    ABC_membrane; ABC transporter transmembrane region

  7. NM_205981.2 → NP_995703.1  Multidrug-Resistance like protein 1, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995703.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTC2, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:988 → 1259
    ABC_membrane; ABC transporter transmembrane region

  8. NM_205969.2 → NP_995691.1  Multidrug-Resistance like protein 1, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995691.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTC1, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 605
    ABC_membrane; ABC transporter transmembrane region

  9. NM_205982.2 → NP_995704.1  Multidrug-Resistance like protein 1, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995704.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTB7, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 605
    ABC_membrane; ABC transporter transmembrane region

  10. NM_165020.3 → NP_723772.2  Multidrug-Resistance like protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723772.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9C5, Q9VK56
    Related
    FBpp0089056
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1548
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1308 → 1528
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 601
    ABC_membrane; ABC transporter transmembrane region

  11. NM_205976.2 → NP_995698.1  Multidrug-Resistance like protein 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995698.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTD0, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 605
    ABC_membrane; ABC transporter transmembrane region

  12. NM_205975.2 → NP_995697.1  Multidrug-Resistance like protein 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995697.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTC9, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:988 → 1259
    ABC_membrane; ABC transporter transmembrane region

  13. NM_205974.2 → NP_995696.1  Multidrug-Resistance like protein 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995696.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTC8, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 605
    ABC_membrane; ABC transporter transmembrane region

  14. NM_205972.2 → NP_995694.1  Multidrug-Resistance like protein 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995694.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTC4, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:988 → 1259
    ABC_membrane; ABC transporter transmembrane region

  15. NM_205971.2 → NP_995693.1  Multidrug-Resistance like protein 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995693.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTC0, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1548
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1308 → 1528
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 605
    ABC_membrane; ABC transporter transmembrane region

  16. NM_205968.2 → NP_995690.1  Multidrug-Resistance like protein 1, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995690.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTB9, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 605
    ABC_membrane; ABC transporter transmembrane region

  17. NM_205978.2 → NP_995700.1  Multidrug-Resistance like protein 1, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995700.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KTB8, Q8T9C5
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 605
    ABC_membrane; ABC transporter transmembrane region

  18. NM_135747.4 → NP_609591.2  Multidrug-Resistance like protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609591.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9C5, Q9I7N0
    Related
    FBpp0089057
    Conserved Domains (4) summary
    TIGR00957
    Location:14 → 1547
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1307 → 1527
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:649 → 848
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:338 → 605
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0WIA2 A0A0S0WIA2
Q7KTB7 Q7KTB7
Q7KTB8 Q7KTB8
Q7KTB9 Q7KTB9
Q7KTC0 Q7KTC0
Q7KTC1 Q7KTC1
Q7KTC2 Q7KTC2
Q7KTC3 Q7KTC3
Q7KTC4 Q7KTC4
Q7KTC5 Q7KTC5
Q7KTC6 Q7KTC6
Q7KTC7 Q7KTC7
Q7KTC8 Q7KTC8
Q7KTC9 Q7KTC9
Q7KTD0 Q7KTD0
Q8T9C5 Q8T9C5
Q9I7N0 Q9I7N0
Q9VK56 Q9VK56

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