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    Fer2LCH Ferritin 2 light chain homologue [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44965, updated on 4-Jan-2025

    Summary

    Official Symbol
    Fer2LCHprovided by FlyBase
    Official Full Name
    Ferritin 2 light chain homologueprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015221
    Locus tag
    Dmel_CG1469
    See related
    AllianceGenome:FB:FBgn0015221
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2LCH; anon-EST:ParkEST264; CG1469; Dmel\CG1469; Fe2LCH; Fer-H; fer2; Fer2; Fer2LC; fer2lch; FerLCH; l(3)00035; l(3)07016; l(3)j2A3; l(3)neo60; l(3)neo63; l(3)s2083; LCH
    Summary
    Enables ferrous iron binding activity. Involved in detoxification of iron ion and iron ion import across plasma membrane. Located in Golgi apparatus. Part of ferritin complex. Is expressed in several structures, including adult brain cell body rind; anterior-posterior subdivision of organism; circulatory system primordium; embryonic/larval hemocyte; and epithelium. [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See Fer2LCH in Genome Data Viewer
    Location:
    99F2-99F2; 3-100 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30387804..30390584)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26213526..26216306)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene headcase Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46114 Neighboring gene Ferritin 1 heavy chain homologue Neighboring gene long non-coding RNA:CR45570 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ferric iron binding  
    enables ferric iron binding  
    enables ferrous iron binding  
    enables ferrous iron binding PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    is_active_in cytoplasm  
    located_in endomembrane system PubMed 
    located_in extracellular region PubMed 
    part_of ferritin complex PubMed 

    General protein information

    Preferred Names
    ferritin 2 light chain homologue
    Names
    CG1469-PA
    CG1469-PB
    CG1469-PC
    CG1469-PD
    CG1469-PE
    Fer2LCH-PA
    Fer2LCH-PB
    Fer2LCH-PC
    Fer2LCH-PD
    Fer2LCH-PE
    Ferritin-Heavy
    Ferritin-Light
    Ferritin2
    ferritin
    ferritin 2 light chain
    ferritin 2 light chain homolog
    ferritin L
    ferritin LCH
    ferritin light chain
    ferritin-2 light chain homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30387804..30390584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080063.4 → NP_524802.2  ferritin 2 light chain homologue, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524802.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4U2, Q9U7A3, Q9VA83
      Related
      FBpp0084986
      Conserved Domains (1) summary
      cd01056
      Location:51 → 223
      Euk_Ferritin; eukaryotic ferritins
    2. NM_170483.1 → NP_733362.1  ferritin 2 light chain homologue, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733362.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4U2, Q9U7A3, Q9VA83
      Related
      FBpp0084987, FBtr0085623
      Conserved Domains (1) summary
      cd01056
      Location:51 → 223
      Euk_Ferritin; eukaryotic ferritins
    3. NM_001276177.1 → NP_001263106.1  ferritin 2 light chain homologue, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263106.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHF0
      Conserved Domains (1) summary
      cd01056
      Location:60 → 232
      Euk_Ferritin; eukaryotic ferritins
    4. NM_001276176.1 → NP_001263105.1  ferritin 2 light chain homologue, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263105.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4U2, Q9U7A3, Q9VA83
      Conserved Domains (1) summary
      cd01056
      Location:51 → 223
      Euk_Ferritin; eukaryotic ferritins
    5. NM_170484.1 → NP_733363.1  ferritin 2 light chain homologue, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733363.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4U2, Q9U7A3, Q9VA83
      Related
      FBpp0084988, FBtr0085624
      Conserved Domains (1) summary
      cd01056
      Location:51 → 223
      Euk_Ferritin; eukaryotic ferritins
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