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CG32473 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41636, updated on 9-Dec-2024

Summary

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Official Symbol
CG32473provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0052473
Locus tag
Dmel_CG32473
See related
AllianceGenome:FB:FBgn0052473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11688; CG8775; Dmel\CG32473; GM08240p
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in several structures, including adult head; embryonic anal pad; epithelium; germline cell; and gut section. Orthologous to human ENPEP (glutamyl aminopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG32473 in Genome Data Viewer
Location:
87E5-87E5; 3-53 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13302648..13312785)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9128370..9138507)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome. Rach EA, et al. Genome Biol, 2009. PMID 19589141, Free PMC Article
  2. Zn2+-induced reversible dissociation of subunit Rpn10/p54 of the Drosophila 26 S proteasome. Kiss P, et al. Biochem J, 2005 Oct 15. PMID 15946124, Free PMC Article
  3. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115
  4. Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila. Monzo K, et al. Dev Biol, 2010 Apr 15. PMID 20122915, Free PMC Article
  5. Differential evolutionary wiring of the tyrosine kinase Btk. Nawaz HM, et al. PLoS One, 2012. PMID 22574122, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG32473-PA
CG32473-PB
CG32473-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13302648..13312785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169503.3 → NP_731786.1  uncharacterized protein Dmel_CG32473, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731786.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJT1, Q9VFW7
    Related
    FBpp0082210
    Conserved Domains (3) summary
    cd09601
    Location:143 → 589
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:135 → 524
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:664 → 979
    ERAP1_C; ERAP1-like C-terminal domain

  2. NM_169504.3 → NP_731787.1  uncharacterized protein Dmel_CG32473, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731787.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAE2, Q8INH6
    Related
    FBpp0082211
    Conserved Domains (3) summary
    cd09601
    Location:151 → 602
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:143 → 537
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:677 → 992
    ERAP1_C; ERAP1-like C-terminal domain

  3. NM_142019.3 → NP_650276.2  uncharacterized protein Dmel_CG32473, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650276.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3PFE8, Q8INH5
    Related
    FBpp0082212
    Conserved Domains (3) summary
    cd09601
    Location:29 → 480
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:21 → 415
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:555 → 870
    ERAP1_C; ERAP1-like C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86P55 Q86P55
Q8IGR1 Q8IGR1
Q8INH5 Q8INH5
Q8INH6 Q8INH6
Q95S62 Q95S62
Q9VFW7 Q9VFW7

Gene LinkOut

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