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Lsp2 Larval serum protein 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45326, updated on 9-Dec-2024

Summary

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Official Symbol
Lsp2provided by FlyBase
Official Full Name
Larval serum protein 2provided by FlyBase
Primary source
FLYBASE:FBgn0002565
Locus tag
Dmel_CG6806
See related
AllianceGenome:FB:FBgn0002565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
C23; CG11538; CG6806; DmeLSP2; Dmel\CG6806; LHP; LSP 2; Lsp-2; LSP-2; lsp2; LSP2; Pt-1
Summary
Involved in motor neuron axon guidance and synaptic target inhibition. Part of larval serum protein complex. Is expressed in adult fat body; adult head; embryonic/larval fat body; and fat body. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Lsp2 in Genome Data Viewer
Location:
68F5-68F5; 3-38 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12129393..12131869)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12122493..12124969)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 68b Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR11538 Neighboring gene antisense RNA:CR45892 Neighboring gene differentially expressed in FDCP 8 homolog Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterisation of oligosaccharides from Drosophila melanogaster glycoproteins. Williams PJ, et al. Biochim Biophys Acta, 1991 Oct 10. PMID 1932070
  2. Drosophila hemolymph proteins: purification, characterization, and genetic mapping of larval serum protein 2 in D. melanogaster. Akam ME, et al. Biochem Genet, 1978 Feb. PMID 417715
  3. The Drosophila Lsp-1 beta gene. A structural and phylogenetic analysis. Massey HC Jr, et al. Eur J Biochem, 1997 Apr 1. PMID 9128742
  4. Protein Differences in Drosophila. I. Drosophila Melanogaster. Hubby JL. Genetics, 1963 Jun. PMID 17248176, Free PMC Article
  5. Overlapping Lsp-2 gene sequences target expression to both the larval and adult Drosophila fat body. Benes H, et al. Insect Mol Biol, 1996 Feb. PMID 8630534

See all (142) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic target inhibition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of larval serum protein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
larval serum protein 2
Names
CG6806-PA
CG6806-PB
Lsp2-PA
Lsp2-PB
Protein-1
larval serum protein-2
larval-hemolymph-protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12129393..12131869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300113.1 → NP_001287042.1  larval serum protein 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287042.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24388, Q9VTT8
    UniProtKB/TrEMBL
    X2JCV2
    Conserved Domains (3) summary
    pfam00372
    Location:163 → 420
    Hemocyanin_M; Hemocyanin, copper containing domain
    pfam03722
    Location:33 → 156
    Hemocyanin_N; Hemocyanin, all-alpha domain
    pfam03723
    Location:430 → 693
    Hemocyanin_C; Hemocyanin, ig-like domain

  2. NM_080077.2 → NP_524816.1  larval serum protein 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524816.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24388, Q9VTT8
    UniProtKB/TrEMBL
    X2JCV2
    Related
    FBpp0088363, FBtr0089324
    Conserved Domains (3) summary
    pfam00372
    Location:163 → 420
    Hemocyanin_M; Hemocyanin, copper containing domain
    pfam03722
    Location:33 → 156
    Hemocyanin_N; Hemocyanin, all-alpha domain
    pfam03723
    Location:430 → 693
    Hemocyanin_C; Hemocyanin, ig-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24388.2 Q24388
X2JCV2 X2JCV2

Gene LinkOut

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