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    nej nejire [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43856, updated on 17-Dec-2024

    Summary

    Official Symbol
    nejprovided by FlyBase
    Official Full Name
    nejireprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261617
    Locus tag
    Dmel_CG15319
    See related
    AllianceGenome:FB:FBgn0261617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0147981.11; anon-WO03040301.89; cbp; Cbp; CBP; CBP/p300; CBP_; CG15319; CG15321; Crbp; dCBP; dKAT3; dmCBP; Dmel\CG15319; l(1)G0112; l(1)G0350; l(1)G0470; Nej; nej CBP; Nejire; p300; P300; p300/CBP
    Old locus tag
    Dmel_CG15321
    Summary
    Enables several functions, including histone H3 acetyltransferase activity; histone methyltransferase binding activity; and transcription coactivator activity. Involved in several processes, including nervous system development; regulation of canonical Wnt signaling pathway; and regulation of cell cycle process. Located in nucleus and polytene chromosome. Part of histone acetyltransferase complex and histone methyltransferase complex. Is expressed in several structures, including adult brain cell body rind; embryonic peripheral glial cell; and larval nervous system. Used to study Rubinstein-Taybi syndrome and alcohol use disorder. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; acute myeloid leukemia; colorectal cancer; and congestive heart failure. Orthologous to human CREBBP (CREB binding protein) and EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See nej in Genome Data Viewer
    Location:
    8F7-8F9; 1-29 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9665442..9687066, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9559475..9581099, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Hecw ubiquitin protein ligase Neighboring gene Protein tyrosine phosphatase Meg2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR42657 Neighboring gene long non-coding RNA:CR44016

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    mobile_element

    • Loc: c9678639-9678154 mobile_element_type = transposon:TART-B{}5270
    • Loc: c9679157-9678736 mobile_element_type = transposon:TART-A{}5266

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding PubMed 
    enables cAMP response element binding protein binding PubMed 
    enables chromatin DNA binding  
    enables histone H3K18 acetyltransferase activity PubMed 
    enables histone H3K27 acetyltransferase activity PubMed 
    enables histone acetyltransferase activity  
    enables histone acetyltransferase activity PubMed 
    enables histone acetyltransferase activity  
    enables histone methyltransferase binding PubMed 
    enables protein binding PubMed 
    enables transcription coactivator activity  
    enables transcription coactivator activity PubMed 
    enables transcription coactivator activity PubMed 
    enables transcription coregulator activity  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in DNA replication checkpoint signaling PubMed 
    involved_in R3/R4 cell fate commitment PubMed 
    involved_in R7 cell differentiation PubMed 
    involved_in chromatin organization PubMed 
    involved_in circadian regulation of gene expression PubMed 
    involved_in compound eye development PubMed 
    involved_in compound eye morphogenesis PubMed 
    involved_in follicle cell of egg chamber development PubMed 
    involved_in glial cell migration PubMed 
    involved_in hemopoiesis PubMed 
    involved_in locomotor rhythm PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway PubMed 
    involved_in neurotransmitter secretion PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway PubMed 
    involved_in positive regulation of smoothened signaling pathway PubMed 
    involved_in positive regulation of smoothened signaling pathway PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of mitotic nuclear division PubMed 
    involved_in regulation of mitotic nuclear division PubMed 
    involved_in synapse assembly PubMed 
    involved_in thermosensory behavior PubMed 
    Component Evidence Code Pubs
    part_of histone acetyltransferase complex  
    part_of histone acetyltransferase complex PubMed 
    part_of histone methyltransferase complex PubMed 
    located_in nucleoplasm PubMed 
    located_in nucleus PubMed 
    located_in polytene chromosome PubMed 
    part_of protein-containing complex PubMed 
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    nejire
    Names
    CBP histone acetyltransferase
    CBP/Nejire
    CG15319-PB
    CG15319-PC
    CG15319-PD
    CG15319-PE
    CREB binding protein
    CREB-binding protein
    cyclic AMP response element binding protein
    drosophila CREB-binding
    drosophila CREB-binding protein
    lethal (1) G0112
    lethal (1) G0350
    lethal (1) G0470
    nej-PB
    nej-PC
    nej-PD
    nej-PE
    protein
    NP_001188575.1
    NP_001188576.1
    NP_001259387.1
    NP_524642.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9665442..9687066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201647.2 → NP_001188576.1  nejire, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188576.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01368, Q9W321
      Conserved Domains (7) summary
      cd05495
      Location:1699 → 1806
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:524 → 594
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:2333 → 2373
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:1818 → 1900
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:1902 → 1933
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02172
      Location:940 → 1018
      KIX; KIX domain
      pfam08214
      Location:1964 → 2277
      HAT_KAT11; Histone acetylation protein
    2. NM_001272458.1 → NP_001259387.1  nejire, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259387.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH39, O01368
      Conserved Domains (7) summary
      cd05495
      Location:1699 → 1806
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:524 → 594
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:2323 → 2363
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:1818 → 1890
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:1892 → 1923
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02172
      Location:940 → 1018
      KIX; KIX domain
      pfam08214
      Location:1954 → 2267
      HAT_KAT11; Histone acetylation protein
    3. NM_001201646.2 → NP_001188575.1  nejire, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188575.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS40, O01368
      Conserved Domains (7) summary
      cd05495
      Location:1705 → 1812
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:530 → 600
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:2339 → 2379
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:1824 → 1906
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:1908 → 1939
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02172
      Location:946 → 1024
      KIX; KIX domain
      pfam08214
      Location:1970 → 2283
      HAT_KAT11; Histone acetylation protein
    4. NM_079903.4 → NP_524642.2  nejire, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524642.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01368, Q9W321
      Related
      FBpp0071337
      Conserved Domains (7) summary
      cd05495
      Location:1699 → 1806
      Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...
      smart00551
      Location:524 → 594
      ZnF_TAZ; TAZ zinc finger, present in p300 and CBP
      cd02337
      Location:2333 → 2373
      ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...
      cd15802
      Location:1818 → 1900
      RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases
      cd15557
      Location:1902 → 1933
      PHD_CBP_p300; PHD finger found in CREB-binding protein (CBP) and histone acetyltransferase p300
      pfam02172
      Location:940 → 1018
      KIX; KIX domain
      pfam08214
      Location:1964 → 2277
      HAT_KAT11; Histone acetylation protein
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