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Aladin aladin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31881, updated on 4-Jan-2025

Summary

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Official Symbol
Aladinprovided by FlyBase
Official Full Name
aladinprovided by FlyBase
Primary source
FLYBASE:FBgn0030122
Locus tag
Dmel_CG16892
See related
AllianceGenome:FB:FBgn0030122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aladin; ALADIN; CG16892; Dmel\CG16892
Summary
Involved in microtubule bundle formation; mitotic spindle assembly; and positive regulation of protein localization to spindle pole body. Located in mitotic spindle and spindle pole. Is expressed in adult head. Human ortholog(s) of this gene implicated in achalasia and triple-A syndrome. Orthologous to human AAAS (aladin WD repeat nucleoporin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Aladin in Genome Data Viewer
Location:
8D4-8D4; 1-27 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9273413..9275653)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9167446..9169686)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene CXXC finger protein 1 Neighboring gene c11.1 Neighboring gene lozenge Neighboring gene long non-coding RNA:CR44534

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation. Carvalhal S, et al. Mol Biol Cell, 2015 Oct 1. PMID 26246606, Free PMC Article
  2. Identification of genes involved in the same pathways using a Hidden Markov Model-based approach. Senf A, et al. Bioinformatics, 2009 Nov 15. PMID 19720676
  3. The genetic basis and adult reproductive consequences of developmental thermal plasticity. Rodrigues LR, et al. J Anim Ecol, 2022 Jun. PMID 35060127, Free PMC Article
  4. Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis. Hampoelz B, et al. Cell, 2019 Oct 17. PMID 31626769, Free PMC Article
  5. Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. Finan D, et al. Proc Natl Acad Sci U S A, 2011 Apr 5. PMID 21368190, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleocytoplasmic transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleocytoplasmic transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein localization to spindle pole body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aladin
Names
Aladin-PA
Aladin-PB
CG16892-PA
CG16892-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9273413..9275653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298120.1 → NP_001285049.1  aladin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285049.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W351
    Conserved Domains (2) summary
    COG2319
    Location:130 → 420
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:184 → 227
    7WD40; WD40 repeat [structural motif]

  2. NM_132329.4 → NP_572557.1  aladin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572557.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W351
    Related
    FBpp0071254
    Conserved Domains (2) summary
    COG2319
    Location:130 → 420
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:184 → 227
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W351.1 Q9W351

Gene LinkOut

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