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Art1 Arginine methyltransferase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41295, updated on 9-Dec-2024

Summary

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Official Symbol
Art1provided by FlyBase
Official Full Name
Arginine methyltransferase 1provided by FlyBase
Primary source
FLYBASE:FBgn0037834
Locus tag
Dmel_CG6554
See related
AllianceGenome:FB:FBgn0037834
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ART1; CG6554; Dart; dart1; Dart1; DART1; Dmel\CG6554; PRMT1
Summary
Enables nuclear receptor corepressor activity and protein-arginine N-methyltransferase activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in adult heart; organism; and ovary. Orthologous to several human genes including PRMT8 (protein arginine methyltransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Art1 in Genome Data Viewer
Location:
86C6-86C6; 3-50 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10786481..10788226, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6612203..6613948, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L37 Neighboring gene RNA-binding protein 1 Neighboring gene Minichromosome maintenance 5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple Arginine Residues Are Methylated in Drosophila Mre11 and Required for Survival Following Ionizing Radiation. Yuan Q, et al. G3 (Bethesda), 2018 May 31. PMID 29695495, Free PMC Article
  2. Long noncoding RNA-dependent methylation of nonhistone proteins. Jantrapirom S, et al. Wiley Interdiscip Rev RNA, 2021 Nov. PMID 33913612
  3. Arginine Methylation Initiates BMP-Induced Smad Signaling. Xu J, et al. Mol Cell, 2013 Jul 11. PMID 23747011, Free PMC Article
  4. Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor. Kimura S, et al. Biochem Biophys Res Commun, 2008 Jul 11. PMID 18468516
  5. Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo. Scaramuzzino C, et al. PLoS One, 2013. PMID 23620769, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that knockdown of Dart1 leds to a reduction in methylation of hFUS P525L and aggravated the neurodegenerative phenotype in transgenic flies
    Title: Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila.
  2. wild type FUS (FUS-WT) specifically interacts with protein arginine methyltransferases 1 and 8 (PRMT1 and PRMT8) and undergoes asymmetric dimethylation.
    Title: Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.
  3. These findings suggest that DART1, a histone arginine methyltransferase, is a co-repressor of EcR that is indispensable for normal pupal development in the intact fly.
    Title: Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor.
  4. Identification of DART1 and DART4, protein arginine methyltransferases, that are expressed in various Drosophila developmental stages
    Title: Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone H4R3 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor corepressor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-arginine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-arginine omega-N asymmetric methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine omega-N asymmetric methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-arginine omega-N monomethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine omega-N monomethyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-arginine methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
arginine methyltransferase 1
Names
Arg methyltransferase 1
Art1-PA
CG6554-PA
NP_650017.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10786481..10788226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141760.4 → NP_650017.1  arginine methyltransferase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650017.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0MJ37, Q9VGW7
    Related
    FBpp0081780
    Conserved Domains (1) summary
    cd02440
    Location:94 → 194
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGW7 Q9VGW7

Gene LinkOut

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