CrebA Cyclic-AMP response element binding protein A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CrebAprovided by FlyBase
Official Full Name: Cyclic-AMP response element binding protein Aprovided by FlyBase
Primary source: FLYBASE:FBgn0004396
Locus tag: Dmel_CG7450
See related: AllianceGenome:FB:FBgn0004396
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Bbbf2; BBF-2; BBF2_DROME; BcDNA:SD05937; BOX B Binding Factor-2; CG7450; CRE-BP; creb; Creb; CREB; Creb A; Creb-A; CREB-a; CREB-A; creba; crebA; CREBA; dCREB; dCreb-A; dCREB-A; dCrebA; dCREBA; DM4; Dmel\CG7450; l(3)03576
Summary: Enables DNA-binding transcription factor activity; chromatin binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in regionalization; regulation of DNA-templated transcription; and salivary gland development. Located in chromatin and nucleolus. Part of transcription regulator complex. Is active in mitochondrial nucleoid. Is expressed in several structures, including adult brain; adult optic lobe; epithelium; gland; and gut section. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 16. Orthologous to human CREB3L1 (cAMP responsive element binding protein 3 like 1) and CREB3L2 (cAMP responsive element binding protein 3 like 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 71E1-71E1; 3-43 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (15535395..15553214)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (15528495..15546314)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Drosophila gene encoding JIG protein (CG14850) is critical for CrebA nuclear trafficking during development.
Title: The Drosophila gene encoding JIG protein (CG14850) is critical for CrebA nuclear trafficking during development.
CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila.
Title: CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila.
CrebA increases secretory capacity through direct transcriptional regulation of the secretory machinery, a subset of secretory cargo, and other key regulators.
Title: CrebA increases secretory capacity through direct transcriptional regulation of the secretory machinery, a subset of secretory cargo, and other key regulators.
Loss of CrebA also partially suppresses mHtt effects on behavior and cell loss and restoration of CrebA can suppress Atx2 effects. Our results indicate a prominent role of Atx2 in mediating mHtt pathology, specifically via its regulation of CrebA, defining a novel molecular pathway in Huntington's disease pathogenesis.
Title: Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons.
Data suggest that CrebA is involved in regulation of infection tolerance in this species; expression of CrebA is regulated in the fat body upon infection; CrebA is required to survive infection and promotes tolerance of bacterial infection; CrebA deficiency leads to ER (endoplasmic reticulum) stress upon bacterial challenge.
Title: Comparative transcriptomics reveals CrebA as a novel regulator of infection tolerance in D. melanogaster.
CrebA deficiency leads to ER stress upon bacterial challenge
Title: Comparative transcriptomics reveals CrebA as a novel regulator of infection tolerance in D. melanogaster.
Drosophila CrebA directly binds the enhancers of secretory pathway genes and is both necessary and sufficient to activate expression of every secretory pathway component gene examined thus far.
Title: The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity.
direct and indirect interactions of the hsromega transcripts with a variety of regulatory proteins like hnRNPs, CBP, proteasome, Drosophila inhibitor of apoptosis protein 1 (DIAP1)
Title: Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models.
The CREB binding protein transcriptional cofactor is necessary and sufficient for down-regulation of DIAP1.
Title: Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death.
CrebA activity is linked to secretory function in multiple tissues
Title: CrebA regulates secretory activity in the Drosophila salivary gland and epidermis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm2116 (e-PCR)
- UniSTS:48744

Dm0281 (e-PCR)
- UniSTS:26808

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chitin-based larval cuticle pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in larval chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in salivary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in salivary gland development	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: Cyclic-AMP response element binding protein A

Names: Box B-binding factor 2; CG7450-PA; CG7450-PB; CREB; CREB-binding protein; CrebA-PA; CrebA-PB; cAMP response element binding protein; cAMP response element binding protein A; cyclic AMP response element binding protein; dCREB-A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

15535395..15553214

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206374.2 → NP_996096.1 Cyclic-AMP response element binding protein A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996096.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29747, Q24282, Q64M72, Q8MQX0, Q9VUQ4

UniProtKB/TrEMBL

Q1LZ07

Conserved Domains (1) summary

cd14689
Location:452 → 502

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
NM_079363.5 → NP_524087.3 Cyclic-AMP response element binding protein A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524087.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P29747, Q24282, Q64M72, Q8MQX0, Q9VUQ4

UniProtKB/TrEMBL

Q1LZ07

Related

FBpp0075311

Conserved Domains (1) summary

cd14689
Location:452 → 502

bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain