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    Myo10A Myosin 10A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32028, updated on 9-Dec-2024

    Summary

    Official Symbol
    Myo10Aprovided by FlyBase
    Official Full Name
    Myosin 10Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0263705
    Locus tag
    Dmel_CG43657
    See related
    AllianceGenome:FB:FBgn0263705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    10A; AAF47980; CG16922; CG2136; CG2174; CG43657; Dmel\CG43657; DmXV; myo10A; Myo20; Syph
    Old locus tag
    Dmel_CG16922; Dmel_CG2174
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Involved in dorsal closure; filopodium assembly; and intracellular protein transport. Located in filopodium and neuronal cell body. Is expressed in adult brain cell body rind; adult head; lamina; and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (myosin XVA). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Myo10A in Genome Data Viewer
    Location:
    9F12-9F13; 1-33 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10930840..10964046)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10824873..10858079)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene vermilion Neighboring gene Rab at 9Fa Neighboring gene Rab at 9Fb Neighboring gene C901 Neighboring gene vexed Neighboring gene SET and MYND domain containing, arthropod-specific, member 4

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    mobile_element

    • Loc: 10939862-10939928 mobile_element_type = transposon:INE-1{}5845

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding  
    enables actin filament binding  
    enables cytoskeletal motor activity  
    enables microfilament motor activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization  
    involved_in dorsal closure PubMed 
    involved_in endocytosis  
    involved_in filopodium assembly PubMed 
    involved_in intracellular protein transport PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton  
    is_active_in actin-based cell projection  
    is_active_in cytoplasm  
    located_in cytoskeleton  
    located_in filopodium PubMed 
    is_active_in membrane  
    part_of myosin complex  
    located_in neuronal cell body PubMed 

    General protein information

    Preferred Names
    myosin 10A
    Names
    CG43657-PC
    CG43657-PD
    CG43657-PE
    CG43657-PF
    Myo10A-PC
    Myo10A-PD
    Myo10A-PE
    Myo10A-PF
    myosin XV
    sisyphus
    unconventional myosin class XV
    NP_001036269.2
    NP_001259435.1
    NP_001285103.1
    NP_572669.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10930840..10964046
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298174.1 → NP_001285103.1  myosin 10A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285103.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZ45
      Conserved Domains (7) summary
      smart00242
      Location:65 → 745
      MYSc; Myosin. Large ATPases
      smart00295
      Location:2732 → 2942
      B41; Band 4.1 homologues
      cd13201
      Location:2938 → 3047
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:2829 → 2934
      FERM_B-lobe; FERM domain B-lobe
      cd01387
      Location:78 → 737
      MYSc_Myo15; class XV mammal-like myosin, motor domain
      pfam00784
      Location:2613 → 2719
      MyTH4; MyTH4 domain
      cl02480
      Location:923 → 1080
      MyTH4; MyTH4 domain
    2. NM_001042804.3 → NP_001036269.2  myosin 10A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036269.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHU0
      Conserved Domains (7) summary
      smart00242
      Location:156 → 836
      MYSc; Myosin. Large ATPases
      smart00295
      Location:2823 → 3033
      B41; Band 4.1 homologues
      cd13201
      Location:3029 → 3138
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:2920 → 3025
      FERM_B-lobe; FERM domain B-lobe
      cd01387
      Location:169 → 828
      MYSc_Myo15; class XV mammal-like myosin, motor domain
      pfam00784
      Location:2704 → 2810
      MyTH4; MyTH4 domain
      cl02480
      Location:1014 → 1171
      MyTH4; MyTH4 domain
    3. NM_132441.3 → NP_572669.2  myosin 10A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572669.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZ45
      Conserved Domains (7) summary
      smart00242
      Location:65 → 745
      MYSc; Myosin. Large ATPases
      smart00295
      Location:2732 → 2942
      B41; Band 4.1 homologues
      cd13201
      Location:2938 → 3047
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:2829 → 2934
      FERM_B-lobe; FERM domain B-lobe
      cd01387
      Location:78 → 737
      MYSc_Myo15; class XV mammal-like myosin, motor domain
      pfam00784
      Location:2613 → 2719
      MyTH4; MyTH4 domain
      cl02480
      Location:923 → 1080
      MyTH4; MyTH4 domain
    4. NM_001272506.1 → NP_001259435.1  myosin 10A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGV5
      Conserved Domains (4) summary
      smart00295
      Location:747 → 957
      B41; Band 4.1 homologues
      cd13201
      Location:953 → 1062
      FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
      cd14473
      Location:844 → 949
      FERM_B-lobe; FERM domain B-lobe
      pfam00784
      Location:628 → 734
      MyTH4; MyTH4 domain
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