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ENGase Endo-beta-N-acetylglucosaminidase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32726, updated on 9-Dec-2024

Summary

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Official Symbol
ENGaseprovided by FlyBase
Official Full Name
Endo-beta-N-acetylglucosaminidaseprovided by FlyBase
Primary source
FLYBASE:FBgn0030839
Locus tag
Dmel_CG5613
See related
AllianceGenome:FB:FBgn0030839
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5613; Dmel\CG5613
Summary
Enables myosin binding activity. Predicted to be involved in N-glycan processing. Predicted to be located in cytoplasm. Orthologous to human ENGASE (endo-beta-N-acetylglucosaminidase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See ENGase in Genome Data Viewer
Location:
16A5-16A5; 1-57 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17423591..17428735)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17317624..17322768)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene BarH1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene presidents-cup Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytosolic O-GlcNAcylation and PNG1 maintain Drosophila gut homeostasis by regulating proliferation and apoptosis. Na HJ, et al. PLoS Genet, 2022 Mar. PMID 35294432, Free PMC Article
  2. A multiplexable TALE-based binary expression system for in vivo cellular interaction studies. Toegel M, et al. Nat Commun, 2017 Nov 21. PMID 29162808, Free PMC Article
  3. Rare recombination events generate sequence diversity among balancer chromosomes in Drosophila melanogaster. Miller DE, et al. Proc Natl Acad Sci U S A, 2016 Mar 8. PMID 26903656, Free PMC Article
  4. Manual curation and phylogenetic analysis of chitinase family genes in the Asian citrus psyllid, Diaphorina citri. Shippy TD, et al. GigaByte, 2022. PMID 36824529, Free PMC Article
  5. Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation. Gelbart ME, et al. Nat Struct Mol Biol, 2009 Aug. PMID 19648925, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables myosin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Endo-beta-N-acetylglucosaminidase
Names
CG5613-PA
CG5613-PB
ENGase-PA
ENGase-PB
NP_573215.1
NP_788923.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17423591..17428735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132987.2 → NP_573215.1  Endo-beta-N-acetylglucosaminidase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573215.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T8V2, Q9VX51
    Related
    FBpp0074205
    Conserved Domains (1) summary
    cd06547
    Location:144 → 476
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

  2. NM_176750.2 → NP_788923.1  Endo-beta-N-acetylglucosaminidase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788923.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H5V8D6, Q86B46
    Related
    FBpp0074206
    Conserved Domains (1) summary
    cd06547
    Location:81 → 413
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86B46 Q86B46
Q8T8V2 Q8T8V2
Q9VX51 Q9VX51

Gene LinkOut

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