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Ndg Nidogen [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36089, updated on 9-Dec-2024

Summary

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Official Symbol
Ndgprovided by FlyBase
Official Full Name
Nidogenprovided by FlyBase
Primary source
FLYBASE:FBgn0026403
Locus tag
Dmel_CG12908
See related
AllianceGenome:FB:FBgn0026403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:CK00552; CG12908; CT32053; Dmel\CG12908; ndg
Summary
An extracellular matrix structural constituent. Involved in basement membrane assembly involved in embryonic body morphogenesis and regulation of basement membrane organization. Located in basement membrane. Is expressed in several structures, including embryonic myoblast; ganglia; mesoderm; muscle cell; and visceral mesoderm derivative. Orthologous to several human genes including NID1 (nidogen 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ndg in Genome Data Viewer
Location:
47A1-47A1; 2-62 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10313891..10322104)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6201396..6209609)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 46a Neighboring gene uncharacterized protein Neighboring gene slowpoke 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interommatidial cells build a tensile collagen network during Drosophila retinal morphogenesis. Ready DF, et al. Curr Biol, 2023 Jun 5. PMID 37209679, Free PMC Article
  2. A scar-like lesion is apparent in basement membrane after wound repair in vivo. Ramos-Lewis W, et al. Matrix Biol, 2018 Dec. PMID 29981372, Free PMC Article
  3. Evidence of Swim secretion and association with extracellular matrix in the Drosophila embryo. Kaltezioti V, et al. Int J Dev Biol, 2022. PMID 34881800
  4. Distinct contributions of ECM proteins to basement membrane mechanical properties in Drosophila. Töpfer U, et al. Development, 2022 May 15. PMID 35575071
  5. Characterization of Drosophila Nidogen/entactin reveals roles in basement membrane stability, barrier function and nervous system patterning. Wolfstetter G, et al. Development, 2019 Jan 16. PMID 30567930

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NDG is not essential for basement (BM) assembly but mediates BM stability and extracellular matrix-dependent neural plasticity during Drosophila development.
    Title: Characterization of Drosophila Nidogen/entactin reveals roles in basement membrane stability, barrier function and nervous system patterning.
  2. Study show that in the Drosophila, Ndg is dispensable for basement membrane assembly and preservation in many tissues, but absolutely required in others.
    Title: Dissection of Nidogen function in Drosophila reveals tissue-specific mechanisms of basement membrane assembly.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables extracellular matrix structural constituent IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in basement membrane assembly involved in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in basement membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of basement membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nidogen
Names
CG12908-PA
CG12908-PC
Ndg-PA
Ndg-PC
Nidogen-like
nidogen/entactin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10313891..10322104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206074.2 → NP_995796.2  nidogen, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995796.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z876, A1Z877, B7FNR1
    Conserved Domains (8) summary
    smart00135
    Location:1152 → 1195
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00539
    Location:108 → 262
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00682
    Location:322 → 549
    G2F; G2 nidogen domain and fibulin
    cd05819
    Location:1067 → 1103
    NHL; NHL repeat [structural motif]
    cl18310
    Location:1059 → 1275
    NHL; NHL repeat unit of beta-propeller proteins
    pfam07645
    Location:591 → 627
    EGF_CA; Calcium-binding EGF domain
    pfam12947
    Location:1001 → 1036
    EGF_3; EGF domain
    cl39070
    Location:1084 → 1123
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B

  2. NM_136731.2 → NP_610575.1  nidogen, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610575.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z876, A1Z877, B7FNR1
    Related
    FBpp0087438
    Conserved Domains (8) summary
    smart00135
    Location:1152 → 1195
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00539
    Location:108 → 262
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00682
    Location:322 → 549
    G2F; G2 nidogen domain and fibulin
    cd05819
    Location:1067 → 1103
    NHL; NHL repeat [structural motif]
    cl18310
    Location:1059 → 1275
    NHL; NHL repeat unit of beta-propeller proteins
    pfam07645
    Location:591 → 627
    EGF_CA; Calcium-binding EGF domain
    pfam12947
    Location:1001 → 1036
    EGF_3; EGF domain
    cl39070
    Location:1084 → 1123
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z877.1 A1Z877

Gene LinkOut

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