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CG18135 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40073, updated on 4-Jan-2025

Summary

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Official Symbol
CG18135provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0036837
Locus tag
Dmel_CG18135
See related
AllianceGenome:FB:FBgn0036837
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG18135
Summary
Enables myosin binding activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in several structures, including adult head; amnioserosa; embryonic anal pad; embryonic/larval midgut; and sense organ. Orthologous to human GPCPD1 (glycerophosphocholine phosphodiesterase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG18135 in Genome Data Viewer
Location:
75F2-75F2; 3-45 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18990026..18998283, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18983126..18991383, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SET and MYND domain containing, arthropod-specific, member 2 Neighboring gene naked cuticle Neighboring gene long non-coding RNA:CR45940

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel insertional allele of the CG18135 gene is associated with severe mutant phenotypes in Drosophila melanogaster. Ratiu AC, et al. Front Genet, 2024. PMID 38957808, Free PMC Article
  2. The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targets. Liu YI, et al. Dev Biol, 2008 Nov 1. PMID 18786525, Free PMC Article
  3. An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase. Zhao X, et al. EMBO Rep, 2022 Feb 3. PMID 35132760, Free PMC Article
  4. CLOCKWORK ORANGE promotes CLOCK-CYCLE activation via the putative Drosophila ortholog of CLOCK INTERACTING PROTEIN CIRCADIAN. Rivas GBS, et al. Curr Biol, 2021 Oct 11. PMID 34331859, Free PMC Article
  5. Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Kadener S, et al. Genes Dev, 2007 Jul 1. PMID 17578907, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glycerophosphocholine phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables starch binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sexual reproduction HEP PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG18135-PA
CG18135-PB
CG18135-PC
CG18135-PD
CG18135-PE
NP_001262028.1
NP_649082.2
NP_788524.1
NP_788525.1
NP_788526.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    18990026..18998283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176346.2 → NP_788524.1  uncharacterized protein Dmel_CG18135, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788524.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV56, Q9VVV6
    Related
    FBpp0074810
    Conserved Domains (3) summary
    cd05814
    Location:32 → 154
    CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
    cd08607
    Location:320 → 607
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    pfam03009
    Location:324 → 610
    GDPD; Glycerophosphoryl diester phosphodiesterase family

  2. NM_140825.3 → NP_649082.2  uncharacterized protein Dmel_CG18135, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649082.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAE6, Q9VVV5
    Related
    FBpp0074809
    Conserved Domains (3) summary
    cd05814
    Location:49 → 171
    CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
    cd08607
    Location:337 → 624
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    pfam03009
    Location:341 → 627
    GDPD; Glycerophosphoryl diester phosphodiesterase family

  3. NM_176347.2 → NP_788525.1  uncharacterized protein Dmel_CG18135, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788525.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV38, Q86BJ0
    Related
    FBpp0074811
    Conserved Domains (3) summary
    cd05814
    Location:107 → 229
    CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
    cd08607
    Location:395 → 682
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    pfam03009
    Location:399 → 685
    GDPD; Glycerophosphoryl diester phosphodiesterase family

  4. NM_176348.2 → NP_788526.1  uncharacterized protein Dmel_CG18135, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788526.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV56, Q86BI9
    Related
    FBpp0074812
    Conserved Domains (3) summary
    cd05814
    Location:166 → 288
    CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
    cd08607
    Location:454 → 741
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    pfam03009
    Location:458 → 744
    GDPD; Glycerophosphoryl diester phosphodiesterase family

  5. NM_001275099.1 → NP_001262028.1  uncharacterized protein Dmel_CG18135, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262028.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV56, M9PI96
    Conserved Domains (3) summary
    cd05814
    Location:45 → 167
    CBM20_Prei4; Prei4, N-terminal CBM20 (carbohydrate-binding module, family 20) domain. Preimplantation protein 4 (Prei4) is a protein of unknown function that is expressed during mouse preimplantation embryogenesis. In addition to the N-terminal CBM20 domain, Prei4 ...
    cd08607
    Location:333 → 620
    GDPD_GDE5; Glycerophosphodiester phosphodiesterase domain of putative mammalian glycerophosphodiester phosphodiesterase GDE5 and similar proteins
    pfam03009
    Location:337 → 623
    GDPD; Glycerophosphoryl diester phosphodiesterase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PI96 M9PI96
Q86BI9 Q86BI9
Q86BJ0 Q86BJ0
Q9VVV5 Q9VVV5
Q9VVV6 Q9VVV6

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