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    PRL Minichromosome maintenance (MCM2/3/5) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828153, updated on 18-Sep-2024

    Summary

    Official Symbol
    PRL
    Official Full Name
    Minichromosome maintenance (MCM2/3/5) family protein
    Primary source
    TAIR:AT4G02060
    Locus tag
    AT4G02060
    See related
    Araport:AT4G02060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MCM7; PROLIFERA; T10M13.7; T10M13_7
    Summary
    Member of the minichromosome maintenance complex, involved in DNA replication initiation. Abundant in proliferating and endocycling tissues. Localized in the nucleus during G1, S and G2 phases of the cell cycle, and are released into the cytoplasmic compartment during mitosis. Binds chromatin.
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    Genomic context

    See PRL in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    17
    Sequence:
    Chromosome: 4; NC_003075.7 (900636..905591)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Vps51/Vps67 family (components of vesicular transport) protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene sugar transporter protein 7 Neighboring gene tRNA-His Neighboring gene MUTS homolog 6 Neighboring gene RING/FYVE/PHD zinc finger superfamily protein

    Pathways from PubChem

    Interactions

    General gene information

    NM_001203726.1
    NM_116437.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA helicase activity  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    part_of MCM complex  
    part_of THO complex PubMed 
    is_active_in chromatin PubMed 
    located_in cytoplasm PubMed 
    NOT located_in cytosol PubMed 
    NOT located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    Minichromosome maintenance (MCM2/3/5) family protein
    NP_001190655.1
    • PROLIFERA (PRL); CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), ATPase, AAA+ type, core (InterPro:IPR003593), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 7 (InterPro:IPR008050); BEST Arabidopsis thaliana protein match is: minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT5G44635.1).
    NP_192115.1
    • PROLIFERA (PRL); FUNCTIONS IN: protein binding, DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: sugar mediated signaling pathway, cell proliferation, DNA-dependent DNA replication initiation, DNA unwinding involved in replication; LOCATED IN: nuclear chromatin, nucleus, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), ATPase, AAA+ type, core (InterPro:IPR003593), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 7 (InterPro:IPR008050); BEST Arabidopsis thaliana protein match is: minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT5G44635.1); Has 4609 Blast hits to 4442 proteins in 796 species: Archae - 407; Bacteria - 660; Metazoa - 1239; Fungi - 945; Plants - 433; Viruses - 2; Other Eukaryotes - 923 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      900636..905591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203726.1 → NP_001190655.1  Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190655.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04721, P43299
      UniProtKB/TrEMBL
      A0A178V048, A0A5S9XP27, A0A654FL69
      Conserved Domains (2) summary
      smart00350
      Location:139 → 638
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:16 → 98
      MCM_N; MCM N-terminal domain
    2. NM_116437.3 → NP_192115.1  Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192115.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04721, P43299
      UniProtKB/TrEMBL
      A0A178V048, A0A5S9XP27, A0A654FL69
      Conserved Domains (2) summary
      smart00350
      Location:139 → 638
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:16 → 98
      MCM_N; MCM N-terminal domain
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