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MCM3 Minichromosome maintenance (MCM2/3/5) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834670, updated on 18-Sep-2024

Summary

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Official Symbol
MCM3
Official Full Name
Minichromosome maintenance (MCM2/3/5) family protein
Primary source
TAIR:AT5G46280
Locus tag
AT5G46280
See related
Araport:AT5G46280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MINICHROMOSOME MAINTENANCE 3; MPL12.6; MPL12_6
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Genomic context

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See MCM3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
15
Sequence:
Chromosome: 5; NC_003076.8 (18769649..18773706, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene ncRNA Neighboring gene 3-ketoacyl-acyl carrier protein synthase I Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of mungbean yellow mosaic India virus (MYMIV) Rep interacting partners using phage display and influence of Arabidopsis thaliana MCM3 on geminivirus DNA replication. Rizvi I, et al. J Biomol Struct Dyn, 2022. PMID 34121621
  2. Arabidopsis thaliana MCM3 single subunit of MCM2-7 complex functions as 3' to 5' DNA helicase. Rizvi I, et al. Protoplasma, 2016 Mar. PMID 25944245
  3. Dynamic localization of the DNA replication proteins MCM5 and MCM7 in plants. Shultz RW, et al. Plant Physiol, 2009 Jun. PMID 19357199, Free PMC Article
  4. The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1. Takahashi N, et al. EMBO J, 2008 Jul 9. PMID 18528439, Free PMC Article
  5. Identification and molecular properties of SUMO-binding proteins in Arabidopsis. Park HC, et al. Mol Cells, 2011 Aug. PMID 21607647, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of mungbean yellow mosaic India virus (MYMIV) Rep interacting partners using phage display and influence of Arabidopsis thaliana MCM3 on geminivirus DNA replication.
    Title: Identification of mungbean yellow mosaic India virus (MYMIV) Rep interacting partners using phage display and influence of Arabidopsis thaliana MCM3 on geminivirus DNA replication.
  2. AtMCM3 possesses in vitro 3' to 5' DNA helicase and ATPase activities and exists in various oligomeric forms including homohexamer.
    Title: Arabidopsis thaliana MCM3 single subunit of MCM2-7 complex functions as 3' to 5' DNA helicase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001344668.1
NM_001344669.1
NM_001344670.1
NM_123997.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA unwinding involved in DNA replication TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
  
part_of THO complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Minichromosome maintenance (MCM2/3/5) family protein
NP_199440.1
  • MINICHROMOSOME MAINTENANCE 3 (MCM3); FUNCTIONS IN: nucleoside-triphosphatase activity, DNA-dependent ATPase activity, DNA binding, nucleotide binding, ATP binding; INVOLVED IN: cell proliferation, DNA-dependent DNA replication initiation, DNA unwinding involved in replication; LOCATED IN: nuclear chromatin; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), ATPase, AAA+ type, core (InterPro:IPR003593), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 3 (InterPro:IPR008046); BEST Arabidopsis thaliana protein match is: Minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT4G02060.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    18769649..18773706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_123997.3 → NP_199440.1  Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199440.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O65400, Q9FL33
    UniProtKB/TrEMBL
    A0A5S9YC52, A0A654G8I2
    Conserved Domains (2) summary
    smart00350
    Location:100 → 634
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:12 → 89
    MCM_N; MCM N-terminal domain

  2. NM_001344669.1 → NP_001332360.1  Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UNC5, A0A1P8BGQ2, A0A654G8I2
    Conserved Domains (2) summary
    smart00350
    Location:100 → 634
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:12 → 89
    MCM_N; MCM N-terminal domain

  3. NM_001344668.1 → NP_001332359.1  Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BGV8

  4. NM_001344670.1 → NP_001332361.1  Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BGQ6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9FL33.1

Gene LinkOut

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