MCM4 Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MCM4
Official Full Name: Minichromosome maintenance (MCM2/3/5) family protein
Primary source: TAIR:AT2G16440
Locus tag: AT2G16440
See related: Araport:AT2G16440
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F16F14.6; F16F14_6; MINICHROMOSOME MAINTENANCE 4
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Genomic context

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See MCM4 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 18

Sequence:: Chromosome: 2; NC_003071.7 (7126279..7130729, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_127197.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IPI Inferred from Physical Interaction more info	PubMed
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA unwinding involved in DNA replication	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MCM complex	IEA Inferred from Electronic Annotation more info
part_of THO complex	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Minichromosome maintenance (MCM2/3/5) family protein

NP_179236.3

MINICHROMOSOME MAINTENANCE 4 (MCM4); FUNCTIONS IN: nucleoside-triphosphatase activity, DNA-dependent ATPase activity, DNA binding, nucleotide binding, ATP binding; INVOLVED IN: cell proliferation, DNA-dependent DNA replication initiation, DNA unwinding involved in replication; LOCATED IN: nuclear chromatin; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), ATPase, AAA+ type, core (InterPro:IPR003593), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 4 (InterPro:IPR008047); BEST Arabidopsis thaliana protein match is: minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT5G44635.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

7126279..7130729 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_127197.5 → NP_179236.3 Minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_179236.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WVF5, Q9SIV8

UniProtKB/TrEMBL

A0A178VLY4, A0A5S9WYF4, A0A654EYE1

Conserved Domains (3) summary

smart00350
Location:232 → 747

MCM; minichromosome maintenance proteins

PHA03307
Location:2 → 76

PHA03307; transcriptional regulator ICP4; Provisional

pfam14551
Location:140 → 231

MCM_N; MCM N-terminal domain