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MCM2 minichromosome maintenance (MCM2/3/5) family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 841056, updated on 18-Sep-2024

Summary

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Official Symbol
MCM2
Official Full Name
minichromosome maintenance (MCM2/3/5) family protein
Primary source
TAIR:AT1G44900
Locus tag
AT1G44900
See related
Araport:AT1G44900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATMCM2; MINICHROMOSOME MAINTENANCE 2; T12C22.19; T12C22_19
Summary
Encodes MCM2 (MINICHROMOSOME MAINTENANCE 2), a protein essential to embryo development. Overexpression results in altered root meristem function.
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Genomic context

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See MCM2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
16
Sequence:
Chromosome: 1; NC_003070.9 (16970214..16974753)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene inner membrane OXA1-like protein Neighboring gene minichromosone maintenance protein Neighboring gene pre-mRNA-processing protein 40A Neighboring gene uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Arabidopsis MCM2 gene is essential to embryo development and its over-expression alters root meristem function. Ni DA, et al. New Phytol, 2009 Oct. PMID 19650778
  2. Arabidopsis thaliana MCM2 plays role(s) in mungbean yellow mosaic India virus (MYMIV) DNA replication. Suyal G, et al. Arch Virol, 2013 May. PMID 23242774
  3. Dynamic localization of the DNA replication proteins MCM5 and MCM7 in plants. Shultz RW, et al. Plant Physiol, 2009 Jun. PMID 19357199, Free PMC Article
  4. The DNA replication checkpoint aids survival of plants deficient in the novel replisome factor ETG1. Takahashi N, et al. EMBO J, 2008 Jul 9. PMID 18528439, Free PMC Article
  5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001198225.2
NM_103572.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA unwinding involved in DNA replication TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of root meristem growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
  
part_of THO complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
minichromosome maintenance (MCM2/3/5) family protein
NP_001185154.1
  • MINICHROMOSOME MAINTENANCE 2 (MCM2); FUNCTIONS IN: DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 2 (InterPro:IPR008045), MCM protein 2, N-terminal (InterPro:IPR021092); BEST Arabidopsis thaliana protein match is: Minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT2G16440.1).
NP_175112.2
  • MINICHROMOSOME MAINTENANCE 2 (MCM2); FUNCTIONS IN: DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: in 7 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 2 (InterPro:IPR008045), MCM protein 2, N-terminal (InterPro:IPR021092); BEST Arabidopsis thaliana protein match is: Minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT2G16440.1); Has 6038 Blast hits to 5672 proteins in 1024 species: Archae - 381; Bacteria - 1139; Metazoa - 1602; Fungi - 1087; Plants - 469; Viruses - 28; Other Eukaryotes - 1332 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    16970214..16974753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198225.2 → NP_001185154.1  minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001185154.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W5C3, F4HPK7
    Conserved Domains (4) summary
    smart00350
    Location:318 → 826
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:67 → 136
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:219 → 334
    MCM_N; MCM N-terminal domain
    cl21455
    Location:542 → 681
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_103572.5 → NP_175112.2  minichromosome maintenance (MCM2/3/5) family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_175112.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q96275, Q9LPD9
    UniProtKB/TrEMBL
    A0A178W5C3
    Conserved Domains (3) summary
    smart00350
    Location:320 → 828
    MCM; minichromosome maintenance proteins
    pfam12619
    Location:67 → 138
    MCM2_N; Mini-chromosome maintenance protein 2
    pfam14551
    Location:222 → 313
    MCM_N; MCM N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LPD9.1

Gene LinkOut

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