(smok* OR diet) AND (mammals[organism] NOT human[organism]) - GEO DataSets

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Select item 2002829411.

Effect of Vitamin D Modulation on the TH2 Cell Transcriptomic Landscape

(Submitter supplied) This dataset profiles the transcriptional response of in vitro polarized TH2 cells treated with calcitriol (active vitamin D) and vehicle controls. RNA-seq was used to identify differentially expressed genes influenced by vitamin D signaling. This study provides insight into the molecular mechanisms through which vitamin D modulates immune responses in TH2 cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
22 Samples

Download data: CSV

Series

Accession:: GSE282941

ID:: 200282941

Select item 2002767352.

NK2R control of energy expenditure and feeding to treat metabolic diseases

(Submitter supplied) The combination of decreasing food intake and increasing energy expenditure represents a powerful strategy for counteracting cardiometabolic diseases, such as obesity and type 2 diabetes1. Yet current approaches require conjugating multiple receptor agonists to achieve both effects2–4 and, thus far, no safe energy-expending option has reached the clinic. Here we show that activation of Neurokinin 2 Receptor (NK2R) is sufficient to suppress appetite centrally and increase energy expenditure peripherally. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE276735

ID:: 200276735

Select item 2002824873.

Effect of dietary increased Vitamin a on urothelial regeneration after Cyclophosphamide induced injury in mice

(Submitter supplied) Vitamin A, predominantly present as all-trans retinol, is an essential nutrient with wide-ranging physiological roles in embryonic development, vision, immunity, reproduction, cell differentiation and proliferation, apoptosis and maintenance of epithelial integrity. In this study the effects of an increased dietary Vitamin A on the regeneration of urinary bladder urothelial cells after severe cyclophosphamide (CP)-induced injury are investigated, focusing on proliferation, apoptosis and differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
18 Samples

Download data: TXT

Series

Accession:: GSE282487

ID:: 200282487

Select item 2002807034.

Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice

(Submitter supplied) Low frequency Jak2VF mutations promote atherosclerosis via IL-1 mediated cross-talk. Therapeutic approaches that increase MERTK or TREM2 could promote plaque stabilization in inflammasome-driven atherosclerosis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE280703

ID:: 200280703

Select item 2002717875.

The effect of ethanolamine phosphate phosphorylase knockout on hepatic gene expression

(Submitter supplied) Ethanolamine phosphate phospholyase (ETNPPL) is an enzyme that irreversibly degrades phospho-ethanolamine (p-ETN), an intermediate in the Kennedy pathway of phosphatidylethanolamine (PE) biosynthesis. PE is the second most abundant phospholipid in mammalian membranes. Disturbance of hepatic phospholipid homeostasis has been linked to the development of metabolic dysfunction-associated steatotic liver disease (MASLD). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
10 Samples

Download data: TXT

Series

Accession:: GSE271787

ID:: 200271787

PubMed

Select item 2002767736.

Magnesium supplementation modifies synovial and splenic transcriptomic signatures and biologic pathways in arthritis mice

(Submitter supplied) Rheumatoid arthritis (RA) is a common chronic autoimmune and inflammatory disease that can cause joint pain and disability. We have recently reported that oral magnesium supplementation significantly reduces disease severity and joint damage in two models of RA. In the synovial tissues. There was an enrichment for differentially expressed genes (DEGs) belonging to pathways implicated in transcription regulation, nuclear receptor signaling, and pathways implicated in RA pathogenesis such as RHO GTPases, RUNX1 pathway, oxidative stress induced senescence, senescence-associated secretory phenotype (SASP) and cell migration in synovial tissues . more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
26 Samples

Download data: XLS

Series

Accession:: GSE276773

ID:: 200276773

Select item 2002801017.

Sphingosine kinase 2 (SphK2) knockout alters metabolic gene expression in an early MASH mouse model

(Submitter supplied) To determine the effect of SphK2 KO on liver metabolic-associated gene expression in an early MASH mouse model To determine the effect of WDSW on liver metabolic-associated gene expression in an early MASH mouse model

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL35014
12 Samples

Download data: RCC

Series

Accession:: GSE280101

ID:: 200280101

Analyze with GEO2R

Select item 2002800838.

Sphingosine kinase 2 (SphK2) knockout increases liver inflammation in an early MASH mouse model

(Submitter supplied) To determine the effect of SphK2 KO on liver inflammation in an early MASH mouse model To determine the effect of WDSW on liver inflammation in an early MASH mouse model

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL35013
12 Samples

Download data: RCC, XLSX

Series

Accession:: GSE280083

ID:: 200280083

Analyze with GEO2R

Select item 2002678429.

The potential global neutralizing effects of AB-free kava against cigarette smoke exposure in mice

(Submitter supplied) RNA seq was applied to the lung and liver tissues from mice with different treatment regimen to evaluate the potential effects on global transcription.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
29 Samples

Download data: CSV

Series

Accession:: GSE267842

ID:: 200267842

PubMed

Select item 20021881310.

High resolution analysis of heterogeneous alveolar type II cells in emphysema and health reveals an airway origin of impaired alveolar regeneration

(Submitter supplied) Emphysema is a major pathological phenotype of chronic obstructive pulmonary disease (COPD) that is characterized by progressive and irreversible alveolar tissue destruction caused by several stressors, such as tobacco smoke and air pollution. It remains incurable in part due to an incomplete understanding of cellular and molecular mechanisms underlying the failure of tissue repair. Here, we have generated a single cell RNA sequencing dataset of enriched epithelial cells from emphysematous parenchymal lung tissue of COPD patients and from healthy controls. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
5 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE218813

ID:: 200218813

PubMed

Select item 20018923911.

Effect of IP6K2-deletion on mRNA expression in mouse spinal cord and duodenum

(Submitter supplied) Inositol pyrophosphates (PP-IPs) regulate diverse physiological processes. Mammalian genome encodes three enzymes (IP6K1-3) synthesizing PP-IP diphosphoinositol pentakisphosphate (IP7). The objective of this experiment is to elucidate the physiological roles of IP6K2-dependent PP-IPs metabolism in gene expression of central nervous system and gastrointestinal tract. Mouse GE 4×44K v2 microarray was employed to comprehensively analyze mRNA expression in spinal cord and duodenum. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11202
4 Samples

Download data: TXT

Series

Accession:: GSE189239

ID:: 200189239

PubMed Analyze with GEO2R

Select item 20027754512.

The methyltransferase MLL4 promotes non-alcoholic steatohepatitis by enhancing NF-κB signaling

(Submitter supplied) Non-alcoholic fatty liver disease (NAFLD) is a growing health problem worldwide, ranging from non-alcoholic fatty liver (NAFL) to the more severe metabolic non-alcoholic steatohepatitis (NASH). Although many studies have elucidated the pathogenesis of NAFLD, the epigenetic regulatory mechanism from NAFL to NASH remains incompletely understood. The histone H3 lysine 4 methyltransferase, MLL4 (also called KMT2D), is a critical epigenetic transcriptional coactivator that mediates overnutrition-induced steatosis in mice, but its potential role in the progression of NASH remains largely unknown. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
7 Samples

Download data: XLSX

Series

Accession:: GSE277545

ID:: 200277545

PubMed

Select item 20026775113.

Time-restricted feeding prevents memory impairments induced by obesogenic diet consumption in mice, in part through hippocampal thyroid hormone signaling.

(Submitter supplied) Objective: The early consumption of calorie-rich diet disrupts circadian rhythms and has adverse effects on memory, yet the effects of timerestricted feeding (TRF) and the underlying molecular mechanisms are unknown. Here, we set out to identify the behavioral and molecular circadian rhythms disruptions generated by juvenile obesogenic diet consumption and their restoration by TRF in male mice. Methods: Metabolic rhythms were measured by indirect calorimetry and memory performances by behavioral tasks. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
71 Samples

Download data: TXT

Series

Accession:: GSE267751

ID:: 200267751

PubMed

Select item 20025059914.

Effect of iron-overload on gene expression in atherosclerosis

(Submitter supplied) The aim of this study was to identify novel key genes and to investigate pathways involved in effect of iron-overload on atherosclerosis

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
9 Samples

Download data: TXT

Series

Accession:: GSE250599

ID:: 200250599

Select item 20021277615.

Repeated fasting events sensitize chromatin and gene expression to support augmented ketogenesis

(Submitter supplied) Mammals evolved to withstand frequent fasting periods due to hepatic production of glucose and ketone bodies. Because the fasting response is transcriptionally-regulated, we asked whether enhancer dynamics impose a transcriptional program during recurrent fasting and whether this produces effects distinct from a single fasting bout. We found that mice undergoing alternate-day fasting (ADF) respond to a following fasting bout profoundly differently from mice first experiencing fasting. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21626 GPL19057
34 Samples

Download data: BEDGRAPH

Series

Accession:: GSE212776

ID:: 200212776

Select item 20028186716.

RNA-Seq analysis of pubertal mammary epithelial cells reveals novel n-3 polyunsaturated fatty acid transcriptomic changes in the fat-1 mouse model

(Submitter supplied) Background/Objectives: Early exposure of nutrients during pubertal mammary gland development may reduce the risk of developing breast cancer later in life. Anticancer, n-3 polyunsaturated fatty acids (n-3 PUFA) are shown to modulate pubertal mammary gland development, however, the mechanisms of action remains unclear. Prior work focuses on effects at the whole tissue level, and little is known at the cellular level, such as mammary epithelial cells (MEC), which are implicated in cancer development. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: CSV

Series

Accession:: GSE281867

ID:: 200281867

Select item 20024040417.

Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
27 Samples

Download data: MTX, TSV

Series

Accession:: GSE240404

ID:: 200240404

Select item 20024040318.

Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction [scRNA-seq]

(Submitter supplied) Myocardial fibrosis leads to cardiac dysfunction and arrhythmias in heart failure with preserved ejection fraction (HFpEF), but the underlying mechanisms remain poorly understood. Here, RNA sequencing identifies Forkhead Box1 (FoxO1) signaling as abnormal in HFpEF hearts. Genetic suppression of FoxO1 alters the intercellular communication between cardiomyocytes and fibroblasts, alleviates abnormal diastolic relaxation, and reduces arrhythmias. more...