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| Status |
Public on Nov 26, 2024 |
| Title |
Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Low frequency Jak2VF mutations promote atherosclerosis via IL-1 mediated cross-talk. Therapeutic approaches that increase MERTK or TREM2 could promote plaque stabilization in inflammasome-driven atherosclerosis.
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| Overall design |
To determine if activating TREM2 could improve atherosclerosis in LAB Jak2VF CH mice, we administered 4D9 or isotype control IgG antibodies by i.p. injection beginning 2 weeks after initiation of the WD and continued injections with the diet for an additional 14 weeks. Digested live aortic cells were used for the Singe cell RNA-Seq analysis.
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| Contributor(s) |
Liu W, Kim E |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Oct 30, 2024 |
| Last update date |
Nov 27, 2024 |
| Contact name |
Chenyi Xue |
| Organization name |
Columbia University
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| Street address |
630 W 168th St.
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10032 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA1179992 |
