Similar studies for GEO DataSets (Select 200097841) - GEO DataSets

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Items: 20

Select item 2000978411.

A sequence-specific core promoter binding transcription factor recruits TRF2 to coordinately transcribe ribosomal protein genes

(Submitter supplied) Ribosomal protein (RP) genes must be coordinately expressed for proper assembly of the ribosome yet the mechanisms that control expression of RP genes in metazoans are poorly understood. Recently, TATA-Binding Protein-related factor 2 (TRF2) rather than the TATA-Binding Protein (TBP) was found to function in transcription of RP genes in Drosophila. Unlike TBP, TRF2 lacks sequence-specific DNA binding activity, so the mechanism by which TRF2 is recruited to promoters is unclear. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19132
4 Samples

Download data: BEDGRAPH

Series

Accession:: GSE97841

ID:: 200097841

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000520292.

Genome-wide localization of Trf2 and TBP in Drosophila embryos

(Submitter supplied) Here we use ChIP-seq in Drosophila embryos to determine the genome-wide binding pattern of TBP and Trf2 using two different antibodies for each factor.

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17275
4 Samples

Download data: BEDGRAPH

Series

Accession:: GSE52029

ID:: 200052029

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Select item 2000508073.

Taf7l cooperates with Trf2 to regulate spermiogenesis

(Submitter supplied) Taf7l (a paralogue of Taf7) and Trf2 (a TBP-related protein) are components of the core promoter complex required for gene/tissue-specific transcription of protein-coding genes by RNA polymerase II. Previous studies reported that Taf7l knockout mice exhibit structurally abnormal sperm, reduced sperm count, weakened motility and compromised fertility. Here we find that continued backcrossing of Taf7l-/Y mice from N5 to N9 produced KO males that are essentially sterile. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
5 Samples

Download data: TXT

Series

Accession:: GSE50807

ID:: 200050807

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Select item 2001015574.

Expression of Hox transcription factors in Drosophila S2 cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13304 GPL21306
42 Samples

Download data: TXT

Series

Accession:: GSE101557

ID:: 200101557

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Select item 2001015565.

Genomic binding profiling upon expression of Ubx in S2 cells

(Submitter supplied) We sought to determine the genomic binding profile of the Drosophila Hox protein Ubx in a homogenous cell system. S2-DRSC cells that have no Hox expression were stably transfected with HA-tagged Ubx under the control of a metallothionein promoter. Upon Ubx expression, we identified high enrichment of Ubx at a large number transcription start sites that colocalises with the GAGA and M1BP.

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13304
3 Samples

Download data: BED

Series

Accession:: GSE101556

ID:: 200101556

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Select item 2001015556.

Gene expression profiling of S2 cells and S2 cells expressing AbdA

(Submitter supplied) We sought to determine the genes regulated by the Drosophila Hox protein AbdA in a homogenous cell system. S2-DRSC cells that have no Hox expression were stably transfected with HA-tagged AbdA under the control of a metallothionein promoter.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13304
6 Samples

Download data: TXT, XLS

Series

Accession:: GSE101555

ID:: 200101555

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Select item 2001015547.

Genomic binding profiling upon expression of AbdA in S2 cells

(Submitter supplied) We sought to determine the genomic binding profile of the Drosophila Hox protein AbdA in a homogenous cell system. S2-DRSC cells that have no Hox expression were stably transfected with HA-tagged AbdA under the control of a metallothionein promoter. Upon AbdA expression, we identified high enrichment of AbdA at a large number transcription start sites that colocalises with the GAGA and M1BP. Genes targeted by GAGA and M1BP contain paused RNA polymerase II and show enrichment of PcG proteins. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21306 GPL13304
33 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE101554

ID:: 200101554

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Select item 2000019308.

Fhl1 and lfh1 ChIP-chip

(Submitter supplied) Fhl1-9myc ChIP-chip, YPD, OD600=0.8, 2 arrays with duplicate spotting of yeast intergenic regions. AND Ifh1-9myc ChIP-chip, cells grown in YPD, OD600=0.8, 2 arrays with duplicate spotting of yeast intergenic regions. Keywords = Fhl1 Keywords: other

Organism:: Saccharomyces cerevisiae

Type:: Genome binding/occupancy profiling by array

Platform:: GPL1689
8 Samples

Download data

Series

Accession:: GSE1930

ID:: 200001930

Select item 2000498429.

ChIP-seq analysis of M1BP in Drosophila S2R+ cells

(Submitter supplied) The genomic distribution of a novel transcription factor called M1BP was determined in Drosophila S2R+ cells

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9521
2 Samples

Download data: BEDGRAPH

Series

Accession:: GSE49842

ID:: 200049842

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Select item 20004663010.

The newly identified transcription factor M1BP ad GAGA factor orchestrate distinct mechanisms of transcriptional regulation on paused genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13782 GPL9521
10 Samples

Download data: BEDGRAPH, PAIR

Series

Accession:: GSE46630

ID:: 200046630

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004662911.

Expression analysis of Drosophila S2R+ cells depleted of M1BP by RNAi

(Submitter supplied) Microarray analysis of gene expression profiles in control and M1BP-depleted Drosophila S2R+ cells. The results of this analyses are reported in Li, J. and D.S. Gilmour (2013) The newly identified transcription factor M1BP ad GAGA factor orchestrate distinct mechanisms of transcriptional regulation on paused genes. The EMBO J, in press.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL13782
8 Samples

Download data: PAIR

Series

Accession:: GSE46629

ID:: 200046629

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20016910512.

M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity (ATAC-seq)

(Submitter supplied) Genome organization is driven by forces affecting transcriptional state, but the relationship between transcription and genome architecture remains unclear. Here, we identified the Drosophila transcription factor Motif 1 Binding Protein (M1BP) in physical association with the gypsy chromatin insulator core complex, including the universal insulator protein CP190. M1BP is required for enhancer-blocking and barrier activities of the gypsy insulator as well as its proper nuclear localization. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL22106
9 Samples

Download data: BIGWIG, NARROWPEAK

Series

Accession:: GSE169105

ID:: 200169105

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Select item 20004587313.

Holo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription.

(Submitter supplied) TFIID is a central player in activated transcription initiation. Recent evidence suggests that the role and composition of TFIID is more diverse than previously understood. To investigate the effects of changing the composition of TFIID in a simple system we depleted TAF1 from Drosophila cells and determined the consequences on metal induced transcription at an inducible gene, Metallothionein B (MtnB). more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13304
4 Samples

Download data: TXT

Series

Accession:: GSE45873

ID:: 200045873

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Select item 20014911614.

Human ZKSCAN3 and Drosophila M1BP are functionally homologous transcription factors in autophagy regulation

(Submitter supplied) Autophagy is an essential cellular process that maintains homeostasis by recycling damaged organelles and nutrients during development and cellular stress. ZKSCAN3 is the sole identified master transcriptional repressor of autophagy in human cell lines. How ZKSCAN3 achieves autophagy repression at the mechanistic or organismal level however still remains to be elucidated. Furthermore, Zkscan3 knockout mice display no discernable autophagy-related phenotypes, suggesting that there may be substantial differences in the regulation of autophagy between normal tissues and tumor cell lines. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19132 GPL13304
18 Samples

Download data: BED, TXT, XLSX

Series

Accession:: GSE149116

ID:: 200149116

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Select item 20012492415.

mRNA Seq analysis of Drosophila wing imaginal discs from Rp mutants and controls in the presence and absence of RpS12 mutations RpS12

(Submitter supplied) mRNA Seq analysis of Drosophila wing imaginal discs from Rp mutants and controls in the presence and absence of RpS12 mutations RpS12 is a regulatory gene required for Xrp1-mediated control of translation and growth in mutants for other ribosomal protein genes Loss of function mutations in Ribosomal Protein (Rp) genes are generally lethal, but heterozygous mutant phenotypes increasingly reveal previously cryptic functions of Rps in growth control and tumor suppression. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13304
9 Samples

Download data: XLS, XLSX

Series

Accession:: GSE124924

ID:: 200124924

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Select item 20012526816.

RNAseq profiling of miR-132/212-deficient CD4+ T cells activated in vitro and in vivo.

(Submitter supplied) Transcriptomic profiling of miR-132/212-deficient and WT CD4 T cells isolated from spleens of L donovani infected mice (d28) to determine the effects of miR-132/212 on CD4 T cell activation in vivo. This was combined by transcriptomic analysis of early stage in vitro activated WT and miR-132/212-deficient CD4 T cells to identify direct miR-132/212 targets in CD4 T cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
25 Samples

Download data: TXT

Series

Accession:: GSE125268

ID:: 200125268

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Select item 20010500917.

GFZF, a glutathione S-transferase protein implicated in cell cycle regulation and hybrid inviability, is a transcriptional co-activator

(Submitter supplied) The core promoter of protein-encoding genes plays a central role in regulating transcription. M1BP is a transcriptional activator that associates with a core promoter element known as Motif 1 that resides at thousand of genes in Drosophila. To gain insight into how M1BP functions, we identified an interacting protein called GFZF. GFZF had been previously identified in genetic screens for factors involved in maintenance of hybrid inviability, the G2-M DNA damage checkpoint, and RAS/MAPK signaling but its contribution to these processes was unknown. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19132
5 Samples

Download data: BEDGRAPH

Series

Accession:: GSE105009

ID:: 200105009

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015871418.

The DYRK1A protein kinase is recruited to a subset of ribosomal protein gene promoters in human and mouse cells [HeLa RNA-seq]

(Submitter supplied) Ribosomal protein genes (RPGs) coding sequences are highly conserved along evolution; however, promoter features and the machinery involved in their transcriptional regulation are not. In eukaryotes, the main genomic elements and players involved in RPG transcriptional regulation have been mostly characterized in Saccharomyces cerevisiae. However, given the lack of evolutionary conservation of the yeast factors, studies in higher eukaryotes have focused on searching for differential enrichment of transcription factor-binding motifs within the RPG promoters. more...