U.S. flag

An official website of the United States government

    • Showing Current items.

    Trl Trithorax-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768981, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trlprovided by FlyBase
    Official Full Name
    Trithorax-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013263
    Locus tag
    Dmel_CG33261
    See related
    AllianceGenome:FB:FBgn0013263
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Adf-2; Adf-2-519; Adf2; anon-EST:fe2E12; CG33261; CG9343; Dmel\CG33261; E(var)3-trl; E(var)62; gaf; Gaf; GAF; gaga; Gaga; GAGA; GAGA factor; l(3)s2325; LBC; Nc70F; NC70F; TfGAGA/Adf-2; trithorax-like; trl; TRL; Trl-GAGA; Try
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; POZ domain binding activity; and protein dimerization activity. Involved in several processes, including amyloid fibril formation; regulation of gene expression; and syncytial blastoderm mitotic cell cycle. Located in chromosome and nucleus. Part of protein-containing complex. Is expressed in several structures, including embryonic/larval midgut primordium; eye photoreceptor cell; ganglia; gut section; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Trl in Genome Data Viewer
    Location:
    70F4-70F4; 3-42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14747929..14761049, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14741029..14754149, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene omega Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA splicing endonuclease subunit 34 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase a Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase b

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA-binding transcription activator activity PubMed 
    enables DNA-binding transcription activator activity PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables POZ domain binding PubMed 
    enables POZ domain binding PubMed 
    enables RNA polymerase II general transcription initiation factor binding PubMed 
    enables chromatin binding PubMed 
    enables core promoter sequence-specific DNA binding PubMed 
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables protein heterodimerization activity PubMed 
    enables protein homodimerization activity PubMed 
    enables sequence-specific DNA binding PubMed 
    enables zinc ion binding PubMed 
    Process Evidence Code Pubs
    involved_in amyloid fibril formation PubMed 
    involved_in chromatin organization PubMed 
    involved_in chromatin remodeling PubMed 
    involved_in chromatin remodeling PubMed 
    involved_in heterochromatin formation PubMed 
    involved_in imaginal disc-derived wing morphogenesis PubMed 
    involved_in maternal-to-zygotic transition of gene expression PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in nuclear division PubMed 
    involved_in nucleosome organization PubMed 
    involved_in nucleosome organization PubMed 
    involved_in oogenesis  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to ecdysone PubMed 
    involved_in sex-chromosome dosage compensation PubMed 
    involved_in spermatogenesis PubMed 
    involved_in syncytial blastoderm mitotic cell cycle PubMed 
    Component Evidence Code Pubs
    located_in euchromatin PubMed 
    is_active_in nucleus  
    is_active_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in pericentric heterochromatin PubMed 
    located_in pericentric heterochromatin PubMed 
    located_in polytene chromosome PubMed 
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    Trithorax-like
    Names
    Adh transcription factor 2
    CG33261-PA
    CG33261-PB
    CG33261-PC
    CG33261-PD
    CG33261-PE
    CG33261-PF
    CG33261-PH
    CG33261-PI
    CG33261-PJ
    CG33261-PK
    GAGA element
    GAGA factor
    GAGA transcription factor
    GAGA-factor
    Trithorax-related
    Trithroax-like
    Trl-PA
    Trl-PB
    Trl-PC
    Trl-PD
    Trl-PE
    Trl-PF
    Trl-PH
    Trl-PI
    Trl-PJ
    Trl-PK
    anon-fast-evolving-2E12
    late boundary complex
    neural conserved at 70F
    transcription-factor-Adh2
    trithorax like
    trithorax-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14747929..14761049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038926.2 → NP_001034015.1  Trithorax-like, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034015.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I1V4Z2, Q2PDY2
      Conserved Domains (3) summary
      pfam09237
      Location:319 → 372
      GAGA; GAGA factor
      smart00225
      Location:35 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:27 → 117
      BTB; BTB/POZ domain
    2. NM_206356.3 → NP_996078.1  Trithorax-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996078.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1Y7, I1V4Z1
      Conserved Domains (3) summary
      pfam09237
      Location:319 → 372
      GAGA; GAGA factor
      smart00225
      Location:35 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:27 → 117
      BTB; BTB/POZ domain
    3. NM_001038924.4 → NP_001034013.2  Trithorax-like, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034013.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      I1V4Z2, Q2PDY1
      Conserved Domains (3) summary
      pfam09237
      Location:319 → 372
      GAGA; GAGA factor
      smart00225
      Location:35 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:27 → 117
      BTB; BTB/POZ domain
    4. NM_001274917.1 → NP_001261846.1  Trithorax-like, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261846.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18349, O18350, O18526, Q08083, Q08605, Q7JN57, Q8MYL3, Q8T387, Q9V3X7, Q9VUH2
      UniProtKB/TrEMBL
      M9PFM7
      Conserved Domains (3) summary
      pfam09237
      Location:319 → 372
      GAGA; GAGA factor
      smart00225
      Location:35 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:27 → 117
      BTB; BTB/POZ domain
    5. NM_206357.3 → NP_996079.1  Trithorax-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996079.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1Y7, I1V4Z1
      Conserved Domains (3) summary
      pfam09237
      Location:319 → 372
      GAGA; GAGA factor
      smart00225
      Location:35 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:27 → 117
      BTB; BTB/POZ domain
    6. NM_206358.4 → NP_996080.1  Trithorax-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996080.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18349, O18350, O18526, Q08083, Q08605, Q7JN57, Q8MYL3, Q8T387, Q9V3X7, Q9VUH2
      UniProtKB/TrEMBL
      A4V1Y6
      Conserved Domains (3) summary
      pfam09237
      Location:319 → 372
      GAGA; GAGA factor
      smart00225
      Location:35 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:27 → 117
      BTB; BTB/POZ domain
    7. NM_206360.1 → NP_996082.1  Trithorax-like, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996082.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18349, O18350, O18526, Q08083, Q08605, Q7JN57, Q8MYL3, Q8T387, Q9V3X7, Q9VUH2
      UniProtKB/TrEMBL
      A4V1Y6
      Conserved Domains (3) summary
      pfam09237
      Location:319 → 372
      GAGA; GAGA factor
      smart00225
      Location:35 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:27 → 117
      BTB; BTB/POZ domain
    8. NM_001038925.3 → NP_001034014.1  Trithorax-like, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034014.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1Y7, I1V4Z1
      Conserved Domains (3) summary
      pfam09237
      Location:319 → 372
      GAGA; GAGA factor
      smart00225
      Location:35 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:27 → 117
      BTB; BTB/POZ domain
    9. NM_206355.4 → NP_996077.1  Trithorax-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996077.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1Y7, I1V4Z1
      Conserved Domains (3) summary
      pfam09237
      Location:319 → 372
      GAGA; GAGA factor
      smart00225
      Location:35 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:27 → 117
      BTB; BTB/POZ domain
    10. NM_206359.4 → NP_996081.1  Trithorax-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996081.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V1Y7, I1V4Z1
      Conserved Domains (3) summary
      pfam09237
      Location:319 → 372
      GAGA; GAGA factor
      smart00225
      Location:35 → 118
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:27 → 117
      BTB; BTB/POZ domain
    External link. Please review our privacy policy.