corto corto [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cortoprovided by FlyBase
Official Full Name: cortoprovided by FlyBase
Primary source: FLYBASE:FBgn0010313
Locus tag: Dmel_CG2530
See related: AllianceGenome:FB:FBgn0010313
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 7128; anon-WO02059370.59; ccf; Ccf; CG2530; Corto; CP-1; Dmel\CG2530; l(3)07128; l(3)neo31; l(3)neo32
Summary: Enables chromatin binding activity and protein homodimerization activity. Involved in several processes, including imaginal disc-derived wing vein specification; mitotic chromosome condensation; and regulation of gene expression. Located in centrosome; nucleus; and polytene chromosome. Part of ESC/E(Z) complex and PRC1 complex. Is expressed in several structures, including anlage in statu nascendi; brain; gut section; head epidermis primordium; and larval imaginal tissue. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 82E7-82E7; 3-47.1 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5077779..5087072, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (903501..912794, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhancer of trithorax/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts.
Title: Enhancer of trithorax/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts.
Elongin C and Corto bind the vein-promoting gene.
Title: The elongin complex antagonizes the chromatin factor Corto for vein versus intervein cell identity in Drosophila wings.
Corto, rl and dMP1 interact during wing tissue differentiation; Corto, ERK(rl) and dMP1 form a complex in the nucleus and co-localize on several sites on polytene chromosomes
Title: The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development.
results reveal a novel epigenetic mechanism involving Corto and Piwi that defines the fate and signaling function of niche cells in maintaining germline stem cells
Title: A Drosophila chromatin factor interacts with the Piwi-interacting RNA mechanism in niche cells to regulate germline stem cell self-renewal.
interaction between the Enhancer of Trithorax and Polycomb Corto and Cyclin G is involved in regulating the balance between cell proliferation and cell differentiation during abdominal epithelium development
Title: Regulation of Abd-B expression by Cyclin G and Corto in the abdominal epithelium of Drosophila.
Corto interacts with Polycomb-group proteins and the GAGA factor.
Title: The Drosophila Corto protein interacts with Polycomb-group proteins and the GAGA factor.
Corto and DSP1 proteins co-localize at 91 sites on polytene chromosomes and co-immunoprecipitate in embryos.
Title: Corto and DSP1 interact and bind to a maintenance element of the Scr Hox gene: understanding the role of Enhancers of trithorax and Polycomb.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epithelium development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterochromatin formation	IC Inferred by Curator more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IPI Inferred from Physical Interaction more info	PubMed
part_of PRC1 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: corto

Names: CG2530-PA; CG2530-PB; CG2530-PC; CG2530-PD; CG2530-PE; centrosomal and chromosomal factor; corto-PA; corto-PB; corto-PC; corto-PD; corto-PE