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HDAC1 Histone deacetylase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38565, updated on 4-Jan-2025

Summary

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Official Symbol
HDAC1provided by FlyBase
Official Full Name
Histone deacetylase 1provided by FlyBase
Primary source
FLYBASE:FBgn0015805
Locus tag
Dmel_CG7471
See related
AllianceGenome:FB:FBgn0015805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7471; dHDAC-1; dHDAC1; DHDAC1; Dmel\CG7471; dmHDA401; DmHDAC1; DmRpd3; drpd3; dRpd3; dRPD3; DRpd3; E(var)3-64BC; Hdac; HDAC; HDAC-1; hdac1; Hdac1; l(3)04556; l(3)64Cc; rpd3; Rpd3; RPD3; Rpd3/HDAC; rpd[3]; Su(var)3-26; Su(var)3-64B; Su(var)326; Su(var)328
Summary
Enables histone deacetylase activity and transcription corepressor activity. Involved in several processes, including determination of adult lifespan; negative regulation of macromolecule biosynthetic process; and negative regulation of response to gamma radiation. Located in chromatin; nucleus; and polytene chromosome interband. Part of Myb complex; nucleoplasm; and transcription repressor complex. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; ganglia; gonad; and imaginal disc. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to several human genes including HDAC2 (histone deacetylase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See HDAC1 in Genome Data Viewer
Location:
64B12-64B12; 3-12 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4626734..4629467)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4626734..4629467)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Src oncogene at 64B Neighboring gene long non-coding RNA:CR45438 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene axotactin Neighboring gene Tubulin tyrosine ligase-like 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila RASopathy models identify disease subtype differences and biomarkers of drug efficacy. Das TK, et al. iScience, 2021 Apr 23. PMID 33855281, Free PMC Article
  2. The histone deacetylase HDAC1 positively regulates Notch signaling during Drosophila wing development. Wang Z, et al. Biol Open, 2018 Feb 20. PMID 29437043, Free PMC Article
  3. The effects of reduced rpd3 levels on fly physiology. Woods JK, et al. Nutr Healthy Aging, 2017 Mar 31. PMID 28447071, Free PMC Article
  4. Identification of Rpd3 as a novel epigenetic regulator of Drosophila FIG 4, a Charcot-Marie-Tooth disease-causing gene. Muraoka Y, et al. Neuroreport, 2021 May 5. PMID 33850086
  5. Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. Rogina B, et al. Science, 2002 Nov 29. PMID 12459580

See all (388) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nutritional stress-induced regulation of microtubule organization and mRNP transport by HDAC1 controlled alpha-tubulin acetylation.
    Title: Nutritional stress-induced regulation of microtubule organization and mRNP transport by HDAC1 controlled α-tubulin acetylation.
  2. Identification of Rpd3 as a novel epigenetic regulator of Drosophila FIG 4, a Charcot-Marie-Tooth disease-causing gene.
    Title: Identification of Rpd3 as a novel epigenetic regulator of Drosophila FIG 4, a Charcot-Marie-Tooth disease-causing gene.
  3. Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism.
    Title: Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism.
  4. Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.
    Title: Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.
  5. The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation.
    Title: The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation.
  6. The functional reduction of Rpd3 rescued the deficient locomotive ability and aberrant morphology of motoneurons induced by the dSLC25A46 knockdown.
    Title: Reduction of Rpd3 suppresses defects in locomotive ability and neuronal morphology induced by the knockdown of Drosophila SLC25A46 via an epigenetic pathway.
  7. The effects of the interaction of Rpd3 and Loco on longevity in D. melanogaster are reported.
    Title: Longer lifespan in the Rpd3 and Loco signaling results from the reduced catabolism in young age with noncoding RNA.
  8. Fuss interacts with Rpd3, and downregulation of rpd3 in gustatory neurons phenocopies the loss of Fuss expression. Surprisingly, there is no colocalization of Fuss with phosphorylated Mad in the larval central nervous system, excluding a direct involvement of Fuss in Dpp/BMP signaling.
    Title: The Drosophila fussel gene is required for bitter gustatory neuron differentiation acting within an Rpd3 dependent chromatin modifying complex.
  9. aken together, these results reveal that inactivation of Rpd3 independently regulates JNK and Yki activities and that both Hippo and JNK signaling pathways contribute to Rpd3 RNAi-induced apoptosis.
    Title: Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling.
  10. Rpd3 accumulates in the nucleolus in the early stage of starvation, upregulates rRNA synthesis, maintains the polysome amount for translation, and finally increases stress tolerance proteins, such as autophagy-related proteins, to acquire starvation stress resistance.
    Title: The Histone Deacetylase Gene Rpd3 Is Required for Starvation Stress Resistance.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables histone deacetylase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in blastoderm segmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of dendrite guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan TAS
Traceable Author Statement
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterochromatin formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin formation IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of negative regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transposable element silencing by piRNA-mediated heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Myb complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuRD complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of NuRD complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of Sin3-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Sin3-type complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome interband IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription repressor complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 1
Names
CG7471-PA
HDAC1-PA
Rpd3
Rpd3 histone deacetylase
histone Deacetylase-1
histone deacetylase
histone deacetylase 1 (HDAC1)
histone deacetylase RPD3
reduced potassium dependency 3
suppressor of variegation 326
NP_647918.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4626734..4629467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139661.4 → NP_647918.2  histone deacetylase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647918.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17429, O77213, Q94517, Q9VZA1
    UniProtKB/TrEMBL
    I1V501
    Related
    FBpp0073173
    Conserved Domains (1) summary
    cl17011
    Location:5 → 372
    Arginase_HDAC; Arginase-like and histone-like hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q94517.2 Q94517

Gene LinkOut

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