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Nedd8 neural precursor cell expressed, developmentally down-regulated gene 8 [ Mus musculus (house mouse) ]

Gene ID: 18002, updated on 13-Jan-2025

Summary

Official Symbol
Nedd8provided by MGI
Official Full Name
neural precursor cell expressed, developmentally down-regulated gene 8provided by MGI
Primary source
MGI:MGI:97301
See related
Ensembl:ENSMUSG00000010376 AllianceGenome:MGI:97301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rub1; NEDD-8
Summary
Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Involved in regulation of postsynapse assembly. Acts upstream of or within protein localization and regulation of transcription by RNA polymerase II. Located in nucleus. Is active in glutamatergic synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human NEDD8 (NEDD8 ubiquitin like modifier). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 174.5), CNS E14 (RPKM 168.5) and 28 other tissues See more
Orthologs
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Genomic context

See Nedd8 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55899720..55909337, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55662263..55671880, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene testis-specific serine kinase 4 Neighboring gene magnesium-dependent phosphatase 1 Neighboring gene guanosine monophosphate reductase 2 Neighboring gene Terf1 (TRF1)-interacting nuclear factor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56300752-56300861 Neighboring gene predicted gene, 25887

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding PubMed 
enables protein tag activity  
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
enables ubiquitin protein ligase binding  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytosol  
located_in cytosol  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 
located_in nucleus PubMed 

General protein information

Preferred Names
ubiquitin-like protein NEDD8
Names
neddylin
neural precursor cell expressed developmentally down-regulated protein 8
ubiquitin-like protein Nedd8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008683.4NP_032709.1  ubiquitin-like protein NEDD8

    See identical proteins and their annotated locations for NP_032709.1

    Status: VALIDATED

    Source sequence(s)
    AI847056, AK146732
    Consensus CDS
    CCDS49498.1
    UniProtKB/Swiss-Prot
    P29595
    UniProtKB/TrEMBL
    Q3TY05, Q3UI46
    Related
    ENSMUSP00000010520.9, ENSMUST00000010520.10
    Conserved Domains (1) summary
    cd01806
    Location:376
    Ubl_NEDD8; ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55899720..55909337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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