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Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 [ Mus musculus (house mouse) ]

Gene ID: 11668, updated on 27-Nov-2024

Summary

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Official Symbol
Aldh1a1provided by MGI
Official Full Name
aldehyde dehydrogenase family 1, subfamily A1provided by MGI
Primary source
MGI:MGI:1353450
See related
Ensembl:ENSMUSG00000053279 AllianceGenome:MGI:1353450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E1; Ahd2; Ahd-2; Aldh1; ALHDII; Raldh1; ALDH-E1; Aldh1a2
Summary
Enables 3-chloroallyl aldehyde dehydrogenase activity and aminobutyraldehyde dehydrogenase (NAD+) activity. Involved in fructose catabolic process; gamma-aminobutyric acid biosynthetic process; and negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including optic cup morphogenesis involved in camera-type eye development; positive regulation of apoptotic process; and retinoid metabolic process. Located in axon and synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 141.6), genital fat pad adult (RPKM 125.0) and 12 other tissues See more
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Genomic context

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See Aldh1a1 in Genome Data Viewer
Location:
19 B; 19 13.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (20469947..20620827)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (20492583..20643463)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45701 Neighboring gene predicted gene, 32689 Neighboring gene predicted gene, 41816 Neighboring gene RIKEN cDNA E030003E18 gene Neighboring gene STARR-seq mESC enhancer starr_45702 Neighboring gene RIKEN cDNA C730002L08 gene Neighboring gene STARR-seq mESC enhancer starr_45704 Neighboring gene glutathione S-transferase kappa 1 Neighboring gene aldehyde dehydrogenase family 1, subfamily A7 Neighboring gene STARR-seq mESC enhancer starr_45705 Neighboring gene STARR-seq mESC enhancer starr_45706 Neighboring gene transmembrane channel-like gene family 1 Neighboring gene STARR-seq mESC enhancer starr_45707 Neighboring gene STARR-seq mESC enhancer starr_45708 Neighboring gene STARR-seq mESC enhancer starr_45709 Neighboring gene STARR-seq mESC enhancer starr_45711 Neighboring gene STARR-seq mESC enhancer starr_45712 Neighboring gene predicted gene, 32750

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Vitamin A metabolism and mucosal immune function are distinct between BALB/c and C57BL/6 mice. Goverse G, et al. Eur J Immunol, 2015 Jan. PMID 25311225
  2. Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system. Anderson DW, et al. Brain Res, 2011 Aug 23. PMID 21784415, Free PMC Article
  3. Murine hepatic aldehyde dehydrogenase 1a1 is a major contributor to oxidation of aldehydes formed by lipid peroxidation. Makia NL, et al. Chem Biol Interact, 2011 May 30. PMID 21256123, Free PMC Article
  4. A novel reporter construct for screening small molecule inhibitors that specifically target self-renewing cancer cells. Shanmugam G, et al. Exp Cell Res, 2019 Oct 15. PMID 31401066
  5. Heterogeneity of vascular and progenitor cell compartments in tumours from MMTV-PyVmT transgenic mice during mammary cancer progression. Smith MJ, et al. Int J Exp Pathol, 2011 Apr. PMID 21059124, Free PMC Article

See all (250) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Autism patient-derived SHANK2B[Y29X] mutation affects the development of ALDH1A1 negative dopamine neuron.
    Title: Autism patient-derived SHANK2B(Y29X) mutation affects the development of ALDH1A1 negative dopamine neuron.
  2. ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms.
    Title: ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control myogenic differentiation of skeletal muscle satellite cells by retinoic acid-dependent and -independent mechanisms.
  3. ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL8/Notch signaling cascade.
    Title: ALDH1A1 overexpression in melanoma cells promotes tumor angiogenesis by activating the IL‑8/Notch signaling cascade.
  4. Global Deletion of ALDH1A1 and ALDH1A2 Genes Does Not Affect Viability but Blocks Spermatogenesis.
    Title: Global Deletion of ALDH1A1 and ALDH1A2 Genes Does Not Affect Viability but Blocks Spermatogenesis.
  5. Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma.
    Title: Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma.
  6. ALDH1A1 regulates postsynaptic mu-opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling.
    Title: ALDH1A1 regulates postsynaptic μ-opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling.
  7. A reporter construct for self-renewing cancer stem cells (CSCs), based on ALDH1A1 expression. Oral cancer cells harboring ALDH1A1-DsRed2 were used to screen inhibitors that target CSCs.
    Title: A novel reporter construct for screening small molecule inhibitors that specifically target self-renewing cancer cells.
  8. These results suggest that retinoic acids produced by Aldh1a1 in the neural retina directs dorsal choroidal vascular development via Sox9 upregulation in the dorsal retinal pigment epithelial cells to enhance retinal pigment epithelial-derived VEGF secretion.
    Title: Neural retina-specific Aldh1a1 controls dorsal choroidal vascular development via Sox9 expression in retinal pigment epithelial cells.
  9. Finally, ATRA replacement suppressed 15-PGDH inhibition-induced tumor progression in KC mice, and ATRA treatment attenuated Aldh1 activity in tumor cells isolated from the pancreas of 15-Pgdh(-/-) KC mice. These findings provide evidence that 15-PGDH inhibition enhances KRAS-driven tumor progression via ATRA depletion in the pancreas. Therefore, ATRA replacement could be a potential strategy for PDAC treatment.
    Title: Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas.
  10. Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO)/paraspeckle protein component 1 (PSPC1)-aldehyde dehydrogenase 1 (NONO/PSPC1-ALDH1A1) in the modulation of Sertoli cells (SCs) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge.
    Title: Synergistic upregulation of NONO and PSPC1 regulates Sertoli cell response to MEHP via modulation of ALDH1A1 signaling.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-deoxyglucosone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3-deoxyglucosone dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables NAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables aldehyde dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables aldehyde dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables aminobutyraldehyde dehydrogenase (NAD+) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables benzaldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables benzaldehyde dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables benzaldehyde dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables retinal dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within 9-cis-retinoic acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 9-cis-retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular detoxification of aldehyde ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular detoxification of aldehyde ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within embryonic eye morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in fructosamine catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fructosamine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fructose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gamma-aminobutyric acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of lens transparency ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of lens transparency ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within optic cup morphogenesis involved in camera-type eye development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retinoic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retinoic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within retinoic acid metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within retinoic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retinol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aldehyde dehydrogenase 1A1
Names
3-deoxyglucosone dehydrogenase
RALDH 1
alcohol dehydrogenase family 1, subfamily A1
alcohol dehydrogenase family 1, subfamily A2
aldehyde dehydrogenase 1, liver cytosolic (class 1)
aldehyde dehydrogenase family 1 member A1
aldehyde dehydrogenase, cytosolic
retinal dehydrogenase 1
NP_001348432.1
NP_001348433.1
NP_001348434.1
NP_001348435.1
NP_038495.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361503.1 → NP_001348432.1  aldehyde dehydrogenase 1A1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AC152162, AC167167
    Consensus CDS
    CCDS29695.1
    UniProtKB/Swiss-Prot
    P24549, Q7TQJ0, Q811J0
    Conserved Domains (1) summary
    cd07141
    Location:15 → 495
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

  2. NM_001361504.1 → NP_001348433.1  aldehyde dehydrogenase 1A1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC152162, AC167167
    Consensus CDS
    CCDS29695.1
    UniProtKB/Swiss-Prot
    P24549, Q7TQJ0, Q811J0
    Conserved Domains (1) summary
    cd07141
    Location:15 → 495
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

  3. NM_001361505.1 → NP_001348434.1  aldehyde dehydrogenase 1A1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC152162, AC167167
    Consensus CDS
    CCDS29695.1
    UniProtKB/Swiss-Prot
    P24549, Q7TQJ0, Q811J0
    Conserved Domains (1) summary
    cd07141
    Location:15 → 495
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

  4. NM_001361506.1 → NP_001348435.1  aldehyde dehydrogenase 1A1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC152162, AC167167
    Consensus CDS
    CCDS29695.1
    UniProtKB/Swiss-Prot
    P24549, Q7TQJ0, Q811J0
    Related
    ENSMUSP00000153410.3, ENSMUST00000225337.3
    Conserved Domains (1) summary
    cd07141
    Location:15 → 495
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

  5. NM_013467.4 → NP_038495.2  aldehyde dehydrogenase 1A1

    See identical proteins and their annotated locations for NP_038495.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AC152162, AC167167
    Consensus CDS
    CCDS29695.1
    UniProtKB/Swiss-Prot
    P24549, Q7TQJ0, Q811J0
    Related
    ENSMUSP00000084918.4, ENSMUST00000087638.4
    Conserved Domains (1) summary
    cd07141
    Location:15 → 495
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    20469947..20620827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24549.5 GenPept UniProtKB/Swiss-Prot:P24549

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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