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Cars2 cysteinyl-tRNA synthetase 2, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 71941, updated on 27-Nov-2024

Summary

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Official Symbol
Cars2provided by MGI
Official Full Name
cysteinyl-tRNA synthetase 2, mitochondrialprovided by MGI
Primary source
MGI:MGI:1919191
See related
Ensembl:ENSMUSG00000056228 AllianceGenome:MGI:1919191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cysRS; 2310051N18Rik; 2410044A07Rik; D530030H10Rik
Summary
Predicted to enable ATP binding activity and cysteine-tRNA ligase activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Located in mitochondrion. Is expressed in metanephros. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 27. Orthologous to human CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 22.7), ovary adult (RPKM 18.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cars2 in Genome Data Viewer
Location:
8 A1.1; 8 5.73 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11564017..11600781, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (11514017..11550781, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RAB20, member RAS oncogene family Neighboring gene RIKEN cDNA E230013L22 gene Neighboring gene NAD(P)HX dehydratase Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:11550723-11550832 Neighboring gene STARR-seq mESC enhancer starr_20716 Neighboring gene STARR-positive B cell enhancer ABC_E9718 Neighboring gene STARR-positive B cell enhancer ABC_E2856 Neighboring gene STARR-positive B cell enhancer ABC_E1101 Neighboring gene inhibitor of growth family, member 1 Neighboring gene ankyrin repeat domain 10 Neighboring gene STARR-seq mESC enhancer starr_20718 Neighboring gene STARR-positive B cell enhancer ABC_E9307 Neighboring gene microRNA 7238

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics. Akaike T, et al. Nat Commun, 2017 Oct 27. PMID 29079736, Free PMC Article
  2. A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34. Vats KR, et al. J Am Soc Nephrol, 2006 Apr. PMID 16565260
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cysteinyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cysteinyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in cysteinyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable cysteine--tRNA ligase, mitochondrial
Names
cysteine--tRNA ligase
cysteinyl-tRNA synthetase 2 (mitochondrial)(putative)
probable cysteinyl-tRNA synthetase, mitochondrial
NP_001346066.1
NP_077210.1
XP_006508953.1
XP_011240384.1
XP_030099634.1
XP_030099635.1
XP_030099636.1
XP_030099637.1
XP_030099638.1
XP_030099639.1
XP_030099640.1
XP_030099641.1
XP_036010192.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359137.1 → NP_001346066.1  probable cysteine--tRNA ligase, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AK038968, BF458069
    UniProtKB/Swiss-Prot
    Q8BYM8, Q9D6U9
    Conserved Domains (1) summary
    cl27478
    Location:27 → 546
    tRNA-synt_1e; tRNA synthetases class I (C) catalytic domain

  2. NM_024248.1 → NP_077210.1  probable cysteine--tRNA ligase, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_077210.1

    Status: VALIDATED

    Source sequence(s)
    AK009937, AK038968, BF458069, CX204497
    Consensus CDS
    CCDS52478.1
    UniProtKB/TrEMBL
    G3X975
    Related
    ENSMUSP00000046453.6, ENSMUST00000049461.7
    Conserved Domains (3) summary
    cd00672
    Location:38 → 342
    CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
    COG0215
    Location:38 → 539
    CysS; Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cl12020
    Location:391 → 427
    Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    11564017..11600781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243775.1 → XP_030099635.1  probable cysteine--tRNA ligase, mitochondrial isoform X4

    Conserved Domains (1) summary
    PTZ00399
    Location:69 → 554
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  2. XM_030243774.1 → XP_030099634.1  probable cysteine--tRNA ligase, mitochondrial isoform X3

    Conserved Domains (1) summary
    PTZ00399
    Location:69 → 555
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  3. XM_006508890.3 → XP_006508953.1  probable cysteine--tRNA ligase, mitochondrial isoform X2

    Conserved Domains (1) summary
    PTZ00399
    Location:27 → 613
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  4. XM_011242082.2 → XP_011240384.1  probable cysteine--tRNA ligase, mitochondrial isoform X1

    Conserved Domains (1) summary
    PTZ00399
    Location:27 → 614
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  5. XM_030243779.2 → XP_030099639.1  probable cysteine--tRNA ligase, mitochondrial isoform X7

    Conserved Domains (1) summary
    PTZ00399
    Location:8 → 430
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  6. XM_036154299.1 → XP_036010192.1  probable cysteine--tRNA ligase, mitochondrial isoform X7

    Conserved Domains (1) summary
    PTZ00399
    Location:8 → 430
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  7. XM_030243777.1 → XP_030099637.1  probable cysteine--tRNA ligase, mitochondrial isoform X6

    Conserved Domains (1) summary
    PTZ00399
    Location:8 → 497
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  8. XM_030243776.1 → XP_030099636.1  probable cysteine--tRNA ligase, mitochondrial isoform X5

    Conserved Domains (1) summary
    PTZ00399
    Location:8 → 498
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  9. XM_030243781.1 → XP_030099641.1  probable cysteine--tRNA ligase, mitochondrial isoform X9

    Conserved Domains (1) summary
    COG0215
    Location:79 → 303
    CysS; Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  10. XM_030243778.1 → XP_030099638.1  probable cysteine--tRNA ligase, mitochondrial isoform X8

    Conserved Domains (1) summary
    PTZ00399
    Location:8 → 431
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

  11. XM_030243780.1 → XP_030099640.1  probable cysteine--tRNA ligase, mitochondrial isoform X9

    Conserved Domains (1) summary
    COG0215
    Location:79 → 303
    CysS; Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_004934882.1 RNA Sequence

    Related
    ENSMUST00000210478.2

  2. XR_004934881.1 RNA Sequence

  3. XR_004934880.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYM8.2 GenPept UniProtKB/Swiss-Prot:Q8BYM8

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