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Cul4 Cullin 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35780, updated on 9-Dec-2024

Summary

Official Symbol
Cul4provided by FlyBase
Official Full Name
Cullin 4provided by FlyBase
Primary source
FLYBASE:FBgn0033260
Locus tag
Dmel_CG8711
See related
AllianceGenome:FB:FBgn0033260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8711; CRL4; cul-4; Cul-4; cul4; CUL4; Cullin4; dCul4; DMcul-4; Dmel\CG8711
Summary
Enables ubiquitin ligase complex scaffold activity. Involved in several processes, including chaeta morphogenesis; eggshell chorion gene amplification; and regulation of signal transduction. Located in nucleus. Part of Cul4-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to several human genes including CUL4A (cullin 4A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Cul4 in Genome Data Viewer
Location:
44A4-44A4; 2-58 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8102260..8106318, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3989765..3993823, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene sugar transporter 3 Neighboring gene sandman Neighboring gene univalents only Neighboring gene Transmembrane protein 63 Neighboring gene under-developed Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex  
part_of Cul4-RING E3 ubiquitin ligase complex PubMed 
part_of cullin-RING ubiquitin ligase complex  
located_in nucleus PubMed 

General protein information

Preferred Names
cullin 4
Names
CG8711-PA
CG8711-PB
Cul4-PA
Cul4-PB
Cullin-4
Cullin4
cul-4
dCullin4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8102260..8106318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136508.4 → NP_610352.2  cullin 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610352.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BI50
    Related
    FBpp0087897
    Conserved Domains (3) summary
    smart00182
    Location:503 → 644
    CULLIN; Cullin
    smart00884
    Location:750 → 815
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:124 → 721
    Cullin; Cullin family
  2. NM_001169613.1 → NP_001163084.1  cullin 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163084.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BI50
    Conserved Domains (3) summary
    smart00182
    Location:503 → 644
    CULLIN; Cullin
    smart00884
    Location:750 → 815
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:124 → 721
    Cullin; Cullin family
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