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L Lobe [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44831, discontinued on 21-Oct-2015
  • This record was discontinued.

Summary

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Gene symbol
L
Gene description
Lobe
Locus tag
Dmel_CG10109
See related
FLYBASE:FBgn0001332
Gene type
protein coding
RNA name
lobe
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10109; Dmel\CG10109; fee; lobe/Akt1s1
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Genomic context

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Location:
51A4-51A4; 2-72.0 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 5.57 latest, but not current Release 5 (GCF_000001215.2) 2R NT_033778.3 (10368692..10384817)

Genomic regions, transcripts, and products

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Genomic Sequence:
NT_033778.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. optimum levels of L and Hth are required to define the boundary between the developing eye and head cuticle on the ventral margin.
    Title: Opposing interactions between homothorax and Lobe define the ventral eye margin of Drosophila eye.
  2. ectopic Jak/STAT signaling and apoptosis are mutually dependent in Lobe mutants, indicating that L reduction makes Jak/STAT signaling harmful to eye development
    Title: Reduction of Lobe leads to TORC1 hypoactivation that induces ectopic Jak/STAT signaling to impair Drosophila eye development.
  3. Lobe gene is required non-autonomously for ventral growth but not dorsal growth, and it mediates the proliferative effect of midline Notch signaling in a ventral-specific manner
    Title: Lobe mediates Notch signaling to control domain-specific growth in the Drosophila eye disc.
  4. Lobe (L) and the Notch (N) ligand Serrate (Ser), which are both involved in ventral eye growth, are required for cell survival in the early eye disc.
    Title: Lobe and Serrate are required for cell survival during early eye development in Drosophila.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General protein information

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Preferred Names
CG10109 gene product from transcript CG10109-RA
Names
CG10109-PA
L-PA
PRAS40
freaky eye
lobe

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    14481187..14497312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080048.4 → NP_524787.1  lobe [Drosophila melanogaster]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V725.1

Gene LinkOut

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