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l(2)dtl lethal-(2)-denticleless [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46326, updated on 9-Dec-2024

Summary

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Official Symbol
l(2)dtlprovided by FlyBase
Official Full Name
lethal-(2)-denticlelessprovided by FlyBase
Primary source
FLYBASE:FBgn0013548
Locus tag
Dmel_CG11295
See related
AllianceGenome:FB:FBgn0013548
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cdt2; Cdt2; CG11295; Dmel\CG11295; DTL83; L2DTL
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in mitotic G2 DNA damage checkpoint signaling and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus. Is expressed in organism. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See l(2)dtl in Genome Data Viewer
Location:
59F6-59F6; 2-104 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23702477..23705403)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19590000..19592926)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene angel Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene salivary glands marred Neighboring gene ALG3, alpha-1,3- mannosyltransferase Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45326

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of null and hypomorphic alleles of the Drosophila l(2)dtl/cdt2 gene: Larval lethality and male fertility. Sloan RS, et al. Fly (Austin), 2012 Jul-Sep. PMID 22722696
  2. Identification of a novel Drosophila melanogaster heat-shock gene, lethal(2)denticleless [l(2)dtl], coding for an 83-kDa protein. Kurzik-Dumke U, et al. Gene, 1996 Jun 1. PMID 8666267
  3. Identification of a novel Drosophila melanogaster gene, angel, a member of a nested gene cluster at locus 59F4,5. Kurzik-Dumke U, et al. Biochim Biophys Acta, 1996 Sep 11. PMID 8809105
  4. The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy. Chittaranjan S, et al. Biol Open, 2015 Apr 2. PMID 25836674, Free PMC Article
  5. Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Shibutani ST, et al. Dev Cell, 2008 Dec. PMID 19081076, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. L(2)dtl is essential for Drosophila development.
    Title: Characterization of null and hypomorphic alleles of the Drosophila l(2)dtl/cdt2 gene: Larval lethality and male fertility.
  2. L2DTL and PCNA interact with CUL4/DDB1 complexes and are involved in CDT1 degradation after DNA damage.
    Title: L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lethal-(2)-denticleless
Names
CG11295-PA
l(2)dtl-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23702477..23705403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080132.3 → NP_524871.1  lethal-(2)-denticleless [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524871.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24371, Q9W1K9
    Related
    FBpp0071994
    Conserved Domains (3) summary
    COG2319
    Location:27 → 442
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:53 → 99
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:52 → 393
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24371.2 Q24371

Gene LinkOut

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