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Wwox WW domain containing oxidoreductase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34090, updated on 4-Jan-2025

Summary

Official Symbol
Wwoxprovided by FlyBase
Official Full Name
WW domain containing oxidoreductaseprovided by FlyBase
Primary source
FLYBASE:FBgn0031972
Locus tag
Dmel_CG7221
See related
AllianceGenome:FB:FBgn0031972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey177; CG7221; Dmel\CG7221; DmWWOX; WWOX
Summary
Involved in defense response to Gram-negative bacterium; regulation of reactive oxygen species metabolic process; and response to ionizing radiation. Located in cytoplasm. Is expressed in adult head and organism. Used to study cancer. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Wwox in Genome Data Viewer
Location:
28D3-28D3; 2-29 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (7999670..8004286, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (7999670..8004286, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene peste Neighboring gene antisense RNA:CR44996 Neighboring gene uncharacterized protein Neighboring gene Starvation-upregulated protein Neighboring gene Serpin 28Dc Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
located_in cytoplasm PubMed 

General protein information

Preferred Names
WW domain containing oxidoreductase
Names
CG7221-PA
CG7221-PB
Wwox-PA
Wwox-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    7999670..8004286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298806.1 → NP_001285735.1  WW domain containing oxidoreductase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285735.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VLU5
    UniProtKB/TrEMBL
    X2J7F1
    Conserved Domains (3) summary
    cd09809
    Location:121 → 402
    human_WWOX_like_SDR_c-like; human WWOX (WW domain-containing oxidoreductase)-like, classical (c)-like SDRs
    smart00456
    Location:13 → 43
    WW; Domain with 2 conserved Trp (W) residues
    PRK06196
    Location:104 → 402
    PRK06196; oxidoreductase; Provisional
  2. NM_135327.4 → NP_609171.1  WW domain containing oxidoreductase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609171.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VLU5
    UniProtKB/TrEMBL
    X2J7F1
    Related
    FBpp0079172
    Conserved Domains (3) summary
    cd09809
    Location:121 → 402
    human_WWOX_like_SDR_c-like; human WWOX (WW domain-containing oxidoreductase)-like, classical (c)-like SDRs
    smart00456
    Location:13 → 43
    WW; Domain with 2 conserved Trp (W) residues
    PRK06196
    Location:104 → 402
    PRK06196; oxidoreductase; Provisional
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