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Act57B Actin 57B [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37368, updated on 4-Jan-2025

Summary

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Official Symbol
Act57Bprovided by FlyBase
Official Full Name
Actin 57Bprovided by FlyBase
Primary source
FLYBASE:FBgn0000044
Locus tag
Dmel_CG10067
See related
AllianceGenome:FB:FBgn0000044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
act 57A; ACT3; Act57; act57A; Act57A; act57b; act57B; Act57b; actin; Actin; actin-57B; Actin-57B; anon-EST:CL2c12; ArpE; BEST:RE38067; C; CG10067; CG30294; chr2R:16452771..16452966; Dmel\CG10067; M; T10
Summary
Involved in ovarian fusome organization and regulation of synapse organization. Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; border follicle cell; dorsal vessel; and larval muscle cell. Used to study hypertrophic cardiomyopathy and hypertrophic cardiomyopathy 11. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1 and thrombocytopenia. Orthologous to human ACTB (actin beta). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Act57B in Genome Data Viewer
Location:
57B5-57B5; 2-92 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20944021..20946431)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16831526..16833936)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Carbonic anhydrase 15 Neighboring gene Retinal Homeobox Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene homeobrain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity. Schmidt W, et al. J Biol Chem, 2020 Nov 13. PMID 32873710, Free PMC Article
  2. Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy. Viswanathan MC, et al. Cell Rep, 2017 Sep 12. PMID 28903042, Free PMC Article
  3. A Drosophila model of Menkes disease reveals a role for DmATP7 in copper absorption and neurodevelopment. Bahadorani S, et al. Dis Model Mech, 2010 Jan-Feb. PMID 20038716
  4. Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages. Kelly KK, et al. Mech Dev, 2002 Jan. PMID 11744367
  5. Pseudo-acetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performance. Viswanathan MC, et al. Front Physiol, 2015. PMID 25972811, Free PMC Article

See all (212) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages.
    Title: Drosophila MEF2 is a direct regulator of Actin57B transcription in cardiac, skeletal, and visceral muscle lineages.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ovarian fusome organization IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
actin 57B
Names
Act57B-PA
Actin-57B
CG10067-PA
F-actin
actin
actin57B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20944021..20946431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079076.4 → NP_523800.1  actin 57B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523800.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53501, Q9W2Q0
    UniProtKB/TrEMBL
    C6TP14, C8VV69
    Related
    FBpp0071448
    Conserved Domains (1) summary
    PTZ00281
    Location:1 → 376
    PTZ00281; actin; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53501.1 P53501

Gene LinkOut

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