U.S. flag

An official website of the United States government

Prosbeta6 Proteasome beta6 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39855, updated on 4-Jan-2025

Summary

Official Symbol
Prosbeta6provided by FlyBase
Official Full Name
Proteasome beta6 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0002284
Locus tag
Dmel_CG4097
See related
AllianceGenome:FB:FBgn0002284
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
b6; beta-6; Beta-6; beta6; beta6_dm; CG4097; Dmel\CG4097; DTS-5; DTS5; l(3)73Ai; l(3)DTS-5; l(3)DTS5; pros26; Pros26; Pros26-DTS; pros26B; pros26beta6; prosbeta6; PSB1_DROME; PSMB1
Summary
Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in several structures, including adult head; adult heart; anterior endoderm; anterior endoderm anlage; and embryonic/larval midgut primordium. Used to study neurodegenerative disease. Orthologous to human PSMB1 (proteasome 20S subunit beta 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Prosbeta6 in Genome Data Viewer
Location:
73B1-73B1; 3-44 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16609400..16610418, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16602500..16603518, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Apollo Neighboring gene pseudo Neighboring gene Artemis Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45865 Neighboring gene Suppressor of ref(2)P sterility Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
is_active_in cytosol  
is_active_in nucleus  
part_of proteasome complex PubMed 
part_of proteasome core complex PubMed 
part_of proteasome core complex  
part_of proteasome core complex, beta-subunit complex  
part_of proteasome core complex, beta-subunit complex  

General protein information

Preferred Names
proteasome beta6 subunit
Names
20S proteasome
CG4097-PA
Prosbeta6-PA
beta6
beta6 proteosome subunit
proteasome 26kD subunit
proteasome beta6
proteasome subunit 20S

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16609400..16610418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079391.3 → NP_524115.1  proteasome beta6 subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524115.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40304, Q9VV84
    Related
    FBpp0075119
    Conserved Domains (2) summary
    COG0638
    Location:24 → 225
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03757
    Location:22 → 235
    proteasome_beta_type_1; proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
External link. Please review our privacy policy.