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Taf4 TBP-associated factor 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39765, updated on 9-Dec-2024

Summary

Official Symbol
Taf4provided by FlyBase
Official Full Name
TBP-associated factor 4provided by FlyBase
Primary source
FLYBASE:FBgn0010280
Locus tag
Dmel_CG5444
See related
AllianceGenome:FB:FBgn0010280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5444; d110; Dmel\CG5444; dmTAF4; dTAF4; dTAFII110; dTAF[[II]]110; l(3)72Dj; p110; SR3-3; SY3-2 TAF110; TAF; taf110; Taf110; TAF110; taf4; TAF4; TAFII110; TAF[II]110; TAF[[II]]; Taf[[II]]110; TAF[[II]]110; TFIID; TFIID 110
Summary
Enables DNA binding activity; DNA-binding transcription factor binding activity; and TFIIA-class transcription factor complex binding activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in transcription initiation at RNA polymerase II promoter. Located in nucleus. Part of transcription factor TFIID complex. Is expressed in epithelial cell; epithelium; male accessory gland; seminal vesicle; and testis. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and spermatogenic failure 13. Orthologous to several human genes including TAF4B (TATA-box binding protein associated factor 4b). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Taf4 in Genome Data Viewer
Location:
72D7-72D8; 3-44 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16113212..16121651)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16106312..16114751)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Zinc-finger protein at 72D Neighboring gene Strumpellin Neighboring gene Phosphoglucose mutase 1 Neighboring gene Signal sequence receptor beta

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
located_in nucleus PubMed 
part_of transcription factor TFIID complex  
part_of transcription factor TFIID complex  
part_of transcription factor TFIID complex PubMed 
part_of transcription factor TFIID complex PubMed 

General protein information

Preferred Names
TBP-associated factor 4
Names
CG5444-PA
CG5444-PB
CG5444-PC
CG5444-PD
CG5444-PE
CG5444-PF
CG5444-PG
CG5444-PH
CG5444-PI
TATA-associated factor 110
TBP associated factor 110
TBP-associated factor
TBP-associated factor 110
TBP-associated factor 110kD
Taf4-PA
Taf4-PB
Taf4-PC
Taf4-PD
Taf4-PE
Taf4-PF
Taf4-PG
Taf4-PH
Taf4-PI
lethal(3)72Dj

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16113212..16121651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079378.4 → NP_524102.1  TBP-associated factor 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524102.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47825, P49845, Q0E8E3, Q1LZ31, Q8T9E0, Q9VUY7
    UniProtKB/TrEMBL
    E1JI11
    Related
    FBpp0075205
    Conserved Domains (2) summary
    smart00549
    Location:293 → 383
    TAFH; TAF homology
    pfam05236
    Location:675 → 917
    TAF4; Transcription initiation factor TFIID component TAF4 family
  2. NM_001144486.3 → NP_001137958.1  TBP-associated factor 4, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137958.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z060
    Conserved Domains (2) summary
    smart00549
    Location:460 → 550
    TAFH; TAF homology
    pfam05236
    Location:842 → 1084
    TAF4; Transcription initiation factor TFIID component TAF4 family
  3. NM_001274998.1 → NP_001261927.1  TBP-associated factor 4, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261927.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PFP3
    Conserved Domains (2) summary
    smart00549
    Location:334 → 424
    TAFH; TAF homology
    pfam05236
    Location:716 → 958
    TAF4; Transcription initiation factor TFIID component TAF4 family
  4. NM_001274999.1 → NP_001261928.1  TBP-associated factor 4, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261928.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PI76
    Conserved Domains (2) summary
    smart00549
    Location:419 → 509
    TAFH; TAF homology
    pfam05236
    Location:801 → 1043
    TAF4; Transcription initiation factor TFIID component TAF4 family
  5. NM_176333.3 → NP_788511.1  TBP-associated factor 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788511.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V201
    Related
    FBpp0075207
    Conserved Domains (2) summary
    smart00549
    Location:223 → 313
    TAFH; TAF homology
    pfam05236
    Location:605 → 847
    TAF4; Transcription initiation factor TFIID component TAF4 family
  6. NM_001169982.2 → NP_001163453.1  TBP-associated factor 4, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163453.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47825, P49845, Q0E8E3, Q1LZ31, Q8T9E0, Q9VUY7
    UniProtKB/TrEMBL
    E1JI11
    Conserved Domains (2) summary
    smart00549
    Location:293 → 383
    TAFH; TAF homology
    pfam05236
    Location:675 → 917
    TAF4; Transcription initiation factor TFIID component TAF4 family
  7. NM_206379.3 → NP_996101.1  TBP-associated factor 4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996101.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V201
    Conserved Domains (2) summary
    smart00549
    Location:223 → 313
    TAFH; TAF homology
    pfam05236
    Location:605 → 847
    TAF4; Transcription initiation factor TFIID component TAF4 family
  8. NM_168651.3 → NP_730109.1  TBP-associated factor 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730109.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47825, P49845, Q0E8E3, Q1LZ31, Q8T9E0, Q9VUY7
    UniProtKB/TrEMBL
    E1JI11
    Related
    FBpp0075206
    Conserved Domains (2) summary
    smart00549
    Location:293 → 383
    TAFH; TAF homology
    pfam05236
    Location:675 → 917
    TAF4; Transcription initiation factor TFIID component TAF4 family
  9. NM_001300148.1 → NP_001287077.1  TBP-associated factor 4, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287077.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47825, P49845, Q0E8E3, Q1LZ31, Q8T9E0, Q9VUY7
    UniProtKB/TrEMBL
    E1JI11
    Conserved Domains (2) summary
    smart00549
    Location:293 → 383
    TAFH; TAF homology
    pfam05236
    Location:675 → 917
    TAF4; Transcription initiation factor TFIID component TAF4 family
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