Trl Trithorax-like [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Trlprovided by FlyBase
Official Full Name: Trithorax-likeprovided by FlyBase
Primary source: FLYBASE:FBgn0013263
Locus tag: Dmel_CG33261
See related: AllianceGenome:FB:FBgn0013263
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Adf-2; Adf-2-519; Adf2; anon-EST:fe2E12; CG33261; CG9343; Dmel\CG33261; E(var)3-trl; E(var)62; gaf; Gaf; GAF; gaga; Gaga; GAGA; GAGA factor; l(3)s2325; LBC; Nc70F; NC70F; TfGAGA/Adf-2; trithorax-like; trl; TRL; Trl-GAGA; Try
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; POZ domain binding activity; and protein dimerization activity. Involved in several processes, including amyloid fibril formation; regulation of gene expression; and syncytial blastoderm mitotic cell cycle. Located in chromosome and nucleus. Part of protein-containing complex. Is expressed in several structures, including embryonic/larval midgut primordium; eye photoreceptor cell; ganglia; gut section; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 70F4-70F4; 3-42 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14747929..14761049, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14741029..14754149, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The misregulation of mitochondria-associated genes caused by GAGA-factor lack promotes autophagic germ cell death in Drosophila testes.
Title: The misregulation of mitochondria-associated genes caused by GAGA-factor lack promotes autophagic germ cell death in Drosophila testes.
Localization of the Drosophila pioneer factor GAF to subnuclear foci is driven by DNA binding and required to silence satellite repeat expression.
Title: Localization of the Drosophila pioneer factor GAF to subnuclear foci is driven by DNA binding and required to silence satellite repeat expression.
GAGA-associated factor fosters loop formation in the Drosophila genome.
Title: GAGA-associated factor fosters loop formation in the Drosophila genome.
The complex role of transcription factor GAGA in germline death during Drosophila spermatogenesis: transcriptomic and bioinformatic analyses.
Title: The complex role of transcription factor GAGA in germline death during Drosophila spermatogenesis: transcriptomic and bioinformatic analyses.
GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo.
Title: GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo.
Pioneer-like factor GAF cooperates with PBAP (SWI/SNF) and NURF (ISWI) to regulate transcription.
Title: Pioneer-like factor GAF cooperates with PBAP (SWI/SNF) and NURF (ISWI) to regulate transcription.
while the Su(Hw) protein remains stably associated with the promoters of these genes at different transcriptional state, the GAF protein level is significantly higher when transcription is activated.
Title: Activation of Su(Hw)-Controlled Genes Is Associated with Increase in GAF Binding.
GAGA protein regulates oogenesis and female fertility in Drosophila.
Title: GAGA protein is required for multiple aspects of Drosophila oogenesis and female fertility.
GAF (Vfl) as an additional factor in regulation of early developmental genes.
Title: Genome-wide search for Zelda-like chromatin signatures identifies GAF as a pioneer factor in early fly development.
GAF interactions with a small subset of partners is direct; however for many others the interactions could be indirect, and depend upon intermediates that serve to diversify the functional capabilities of the GAF protein
Title: The GAGA factor regulatory network: Identification of GAGA factor associated proteins.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables POZ domain binding	IDA Inferred from Direct Assay more info	PubMed
enables POZ domain binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II general transcription initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables core promoter sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in amyloid fibril formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	NAS Non-traceable Author Statement more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maternal-to-zygotic transition of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ecdysone	IDA Inferred from Direct Assay more info	PubMed
involved_in sex-chromosome dosage compensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in syncytial blastoderm mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in pericentric heterochromatin	TAS Traceable Author Statement more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Trithorax-like

Names: Adh transcription factor 2; CG33261-PA; CG33261-PB; CG33261-PC; CG33261-PD; CG33261-PE; CG33261-PF; CG33261-PH; CG33261-PI; CG33261-PJ; CG33261-PK; GAGA element; GAGA factor; GAGA transcription factor; GAGA-factor; Trithorax-related; Trithroax-like; Trl-PA; Trl-PB; Trl-PC; Trl-PD; Trl-PE; Trl-PF; Trl-PH; Trl-PI; Trl-PJ; Trl-PK; anon-fast-evolving-2E12; late boundary complex; neural conserved at 70F; transcription-factor-Adh2; trithorax like; trithorax-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

14747929..14761049 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001038926.2 → NP_001034015.1 Trithorax-like, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001034015.1

Status: REVIEWED

UniProtKB/TrEMBL

I1V4Z2, Q2PDY2

Conserved Domains (3) summary

pfam09237
Location:319 → 372

GAGA; GAGA factor

smart00225
Location:35 → 118

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:27 → 117

BTB; BTB/POZ domain
NM_206356.3 → NP_996078.1 Trithorax-like, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996078.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V1Y7, I1V4Z1

Conserved Domains (3) summary

pfam09237
Location:319 → 372

GAGA; GAGA factor

smart00225
Location:35 → 118

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:27 → 117

BTB; BTB/POZ domain
NM_001038924.4 → NP_001034013.2 Trithorax-like, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001034013.2

Status: REVIEWED

UniProtKB/TrEMBL

I1V4Z2, Q2PDY1

Conserved Domains (3) summary

pfam09237
Location:319 → 372

GAGA; GAGA factor

smart00225
Location:35 → 118

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:27 → 117

BTB; BTB/POZ domain
NM_001274917.1 → NP_001261846.1 Trithorax-like, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261846.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18349, O18350, O18526, Q08083, Q08605, Q7JN57, Q8MYL3, Q8T387, Q9V3X7, Q9VUH2

UniProtKB/TrEMBL

M9PFM7

Conserved Domains (3) summary

pfam09237
Location:319 → 372

GAGA; GAGA factor

smart00225
Location:35 → 118

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:27 → 117

BTB; BTB/POZ domain
NM_206357.3 → NP_996079.1 Trithorax-like, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996079.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V1Y7, I1V4Z1

Conserved Domains (3) summary

pfam09237
Location:319 → 372

GAGA; GAGA factor

smart00225
Location:35 → 118

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:27 → 117

BTB; BTB/POZ domain
NM_206358.4 → NP_996080.1 Trithorax-like, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996080.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18349, O18350, O18526, Q08083, Q08605, Q7JN57, Q8MYL3, Q8T387, Q9V3X7, Q9VUH2

UniProtKB/TrEMBL

A4V1Y6

Conserved Domains (3) summary

pfam09237
Location:319 → 372

GAGA; GAGA factor

smart00225
Location:35 → 118

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:27 → 117

BTB; BTB/POZ domain
NM_206360.1 → NP_996082.1 Trithorax-like, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996082.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18349, O18350, O18526, Q08083, Q08605, Q7JN57, Q8MYL3, Q8T387, Q9V3X7, Q9VUH2

UniProtKB/TrEMBL

A4V1Y6

Conserved Domains (3) summary

pfam09237
Location:319 → 372

GAGA; GAGA factor

smart00225
Location:35 → 118

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:27 → 117

BTB; BTB/POZ domain
NM_001038925.3 → NP_001034014.1 Trithorax-like, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001034014.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V1Y7, I1V4Z1

Conserved Domains (3) summary

pfam09237
Location:319 → 372

GAGA; GAGA factor

smart00225
Location:35 → 118

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:27 → 117

BTB; BTB/POZ domain
NM_206355.4 → NP_996077.1 Trithorax-like, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996077.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V1Y7, I1V4Z1

Conserved Domains (3) summary

pfam09237
Location:319 → 372

GAGA; GAGA factor

smart00225
Location:35 → 118

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:27 → 117

BTB; BTB/POZ domain
NM_206359.4 → NP_996081.1 Trithorax-like, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996081.1

Status: REVIEWED

UniProtKB/TrEMBL

A4V1Y7, I1V4Z1

Conserved Domains (3) summary

pfam09237
Location:319 → 372

GAGA; GAGA factor

smart00225
Location:35 → 118

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00651
Location:27 → 117

BTB; BTB/POZ domain