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Psc Posterior sex combs [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36431, updated on 4-Jan-2025

Summary

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Official Symbol
Pscprovided by FlyBase
Official Full Name
Posterior sex combsprovided by FlyBase
Primary source
FLYBASE:FBgn0005624
Locus tag
Dmel_CG3886
See related
AllianceGenome:FB:FBgn0005624
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
49Ea; CG3886; D-Bmi; Dmel\CG3886; dPSC; l(2)49Ea; l(2)Psc; l(2)vr14; psc; PSC; Psc1; Su(z)2-C; Suz2; vr14
Summary
Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in anterior/posterior axis specification; regulation of gene expression; and syncytial blastoderm mitotic cell cycle. Located in nucleus. Part of PRC1 complex. Is expressed in several structures, including brain; central nervous system; embryonic/larval salivary gland; imaginal disc; and larval ventral nerve cord. Orthologous to human PCGF2 (polycomb group ring finger 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Psc in Genome Data Viewer
Location:
49E6-49E6; 2-67 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12965997..12980994, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8853502..8868499, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44339 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence. Beh LY, et al. Proc Natl Acad Sci U S A, 2012 May 1. PMID 22517748, Free PMC Article
  2. A bridging model for persistence of a polycomb group protein complex through DNA replication in vitro. Lo SM, et al. Mol Cell, 2012 Jun 29. PMID 22749399, Free PMC Article
  3. Chromatin modification by PSC occurs at one PSC per nucleosome and does not require the acidic patch of histone H2A. Lo SM, et al. PLoS One, 2012. PMID 23071745, Free PMC Article
  4. Shaping epigenetic memory via genomic bookmarking. Michieletto D, et al. Nucleic Acids Res, 2018 Jan 9. PMID 29190361, Free PMC Article
  5. Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene. Brunk BP, et al. Nature, 1991 Sep 26. PMID 1833647

See all (397) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNA Binding Reorganizes the Intrinsically Disordered C-Terminal Region of PSC in Drosophila PRC1.
    Title: DNA Binding Reorganizes the Intrinsically Disordered C-Terminal Region of PSC in Drosophila PRC1.
  2. Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.
    Title: Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.
  3. The Psc-Su(z)2 locus is flanked by insulator elements that may protect neighboring genes from inappropriate silencing.
    Title: Regulation of Polycomb group genes Psc and Su(z)2 in Drosophila melanogaster.
  4. study describes a transcription-independent function for PSC in regulating the destruction of cyclin B; PSC appears to mediate both developmental gene silencing and posttranslational control of mitosis
    Title: Transcription-independent function of Polycomb group protein PSC in cell cycle control.
  5. Posterior sex combs (Psc), which encodes a core Polycomb-repressive complex 1 (PRC1) component, functions redundantly with a similar gene, Suppressor of zeste two [Su(z)2], to restrict follicle stem cell (FSC) self-renewal in the Drosophila ovary
    Title: Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling.
  6. Psc encodes at least two functions, complex formation and the inhibition of remodeling and transcription, which require different regions of the protein.
    Title: Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables promoter-specific chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in syncytial blastoderm mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ventral cord development HMP PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
posterior sex combs
Names
CG3886-PA
CG3886-PB
CG3886-PC
Psc-PA
Psc-PB
Psc-PC
posterior sex comb
posterior-sex-combs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    12965997..12980994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299440.1 → NP_001286369.1  posterior sex combs, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286369.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35820, Q9V6I9
    UniProtKB/TrEMBL
    D0Z760
    Conserved Domains (2) summary
    pfam00097
    Location:263 → 301
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam16207
    Location:384 → 465
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

  2. NM_079001.3 → NP_523725.2  posterior sex combs, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523725.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35820, Q9V6I9
    UniProtKB/TrEMBL
    D0Z760
    Related
    FBpp0086911
    Conserved Domains (2) summary
    pfam00097
    Location:263 → 301
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam16207
    Location:384 → 465
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

  3. NM_001299439.1 → NP_001286368.1  posterior sex combs, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286368.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35820, Q9V6I9
    UniProtKB/TrEMBL
    D0Z760
    Conserved Domains (2) summary
    pfam00097
    Location:263 → 301
    zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
    pfam16207
    Location:384 → 465
    RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D0Z760 D0Z760
P35820.2 P35820

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