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    sba six-banded [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42824, updated on 9-Dec-2024

    Summary

    Official Symbol
    sbaprovided by FlyBase
    Official Full Name
    six-bandedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016754
    Locus tag
    Dmel_CG13598
    See related
    AllianceGenome:FB:FBgn0016754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF56201; CG13598; Dm Sba; dMBD5/6; Dmel\CG13598; DMTF125; F125; MBD5; SBA; Tf125; TF125
    Summary
    Predicted to enable chromatin binding activity. Predicted to be active in chromocenter and nucleus. Human ortholog(s) of this gene implicated in autism spectrum disorder and autosomal dominant intellectual developmental disorder 1. Orthologous to several human genes including MBD5 (methyl-CpG binding domain protein 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See sba in Genome Data Viewer
    Location:
    95C9-95C12; 3-81 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23894174..23922973, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19719896..19748695, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Transcription-factor-IIA-S Neighboring gene testis-specifically expressed bromodomain containing protein-1 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Nuclear division cycle 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding  
    enables chromatin binding  
    Component Evidence Code Pubs
    located_in nucleus  

    General protein information

    Preferred Names
    six-banded
    Names
    CG13598-PC
    CG13598-PD
    CG13598-PE
    CG13598-PF
    CG13598-PG
    CG13598-PH
    CG13598-PI
    TF125 type II
    methyl-CpG-binding domain protein 5/6
    sba-PC
    sba-PD
    sba-PE
    sba-PF
    sba-PG
    sba-PH
    sba-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23894174..23922973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176549.3NP_788726.2  six-banded, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788726.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K7E4, A0A0B4KHQ9, A0A0B4KHZ2, A0A0C4DHB2, A8JR92, A8JR93, Q24552, Q94892
      UniProtKB/TrEMBL
      Q95TH4
      Conserved Domains (2) summary
      smart00391
      Location:241315
      MBD; Methyl-CpG binding domain
      cl02554
      Location:13441440
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
    2. NM_170094.4NP_732911.2  six-banded, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732911.2

      Status: REVIEWED

      Conserved Domains (1) summary
      smart00391
      Location:241315
      MBD; Methyl-CpG binding domain
    3. NM_001260342.2NP_001247271.1  six-banded, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247271.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TH4
      Conserved Domains (1) summary
      smart00391
      Location:241315
      MBD; Methyl-CpG binding domain
    4. NM_001104423.2NP_001097893.1  six-banded, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097893.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K7E4, A0A0B4KHQ9, A0A0B4KHZ2, A0A0C4DHB2, A8JR92, A8JR93, Q24552, Q94892
      UniProtKB/TrEMBL
      Q95TH4
      Conserved Domains (2) summary
      smart00391
      Location:241315
      MBD; Methyl-CpG binding domain
      cl02554
      Location:13441440
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
    5. NM_001275959.1NP_001262888.1  six-banded, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262888.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TH4
      Conserved Domains (2) summary
      smart00391
      Location:241315
      MBD; Methyl-CpG binding domain
      cl02554
      Location:13441440
      PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
    6. NM_001275960.1NP_001262889.1  six-banded, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262889.1

      Status: REVIEWED

      Conserved Domains (1) summary
      smart00391
      Location:241315
      MBD; Methyl-CpG binding domain
    7. NM_001104422.3NP_001097892.1  six-banded, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097892.1

      Status: REVIEWED

      Conserved Domains (1) summary
      smart00391
      Location:241315
      MBD; Methyl-CpG binding domain
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