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CCT3 Chaperonin containing TCP1 subunit 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42029, updated on 9-Dec-2024

Summary

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Official Symbol
CCT3provided by FlyBase
Official Full Name
Chaperonin containing TCP1 subunit 3provided by FlyBase
Primary source
FLYBASE:FBgn0015019
Locus tag
Dmel_CG8977
See related
AllianceGenome:FB:FBgn0015019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cct-gamma; Cct-gamma; cct3; Cct3; cctg; Cctg; cctgamma; Cctgamma; CCTgamma; CG8977; Dmel\CG8977; geneY; Tcp-1-gamma; Tcp-1gamma; Tcp1-gamma; TCP1-gamma; TCPG_DROME; vine; Y
Summary
Predicted to enable unfolded protein binding activity. Involved in lumen formation, open tracheal system and terminal branching, open tracheal system. Predicted to be part of chaperonin-containing T-complex. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; germline cell; gut section; and larval muscle cell. Used to study intrinsic cardiomyopathy. Orthologous to human CCT3 (chaperonin containing TCP1 subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CCT3 in Genome Data Viewer
Location:
89D6-89D6; 3-59 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16647605..16649978)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12473327..12475700)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene nonA-like Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 Neighboring gene uncharacterized protein Neighboring gene Methyltransferase like 4 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila gene collection: identification of putative full-length cDNAs for 70% of D. melanogaster genes. Stapleton M, et al. Genome Res, 2002 Aug. PMID 12176937, Free PMC Article
  2. Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila. Syed A, et al. Dev Biol, 2019 Jan 1. PMID 30539716, Free PMC Article
  3. Drosophila melanogaster P1 genomic clone DS05563 contains the chaperonin-encoding gene Cctg. Walkley NA, et al. Gene, 1996 Jun 1. PMID 8666276
  4. CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease. Lottes EN, et al. Cells, 2024 Jun 13. PMID 38920658, Free PMC Article
  5. TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan. Melkani GC, et al. FEBS Lett, 2017 Nov. PMID 28963798, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lumen formation, open tracheal system HMP PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in terminal branching, open tracheal system HMP PubMed 
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chaperonin-containing T-complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
chaperonin containing TCP1 subunit 3
Names
CCT-gamma protein
CCT3-PA
CCT3-PB
CCT3-PC
CCT3-PD
CCTgamma-like
CG8977-PA
CG8977-PB
CG8977-PC
CG8977-PD
TCP-1 subunit 3gamma
cctgamma
chaperonin-containing t-complex protein-1 gamma subunit like
predicted gene Y
vine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16647605..16649978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169727.2 → NP_732167.1  chaperonin containing TCP1 subunit 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732167.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48605, Q9VER9
    UniProtKB/TrEMBL
    A4V303
    Related
    FBpp0082788
    Conserved Domains (2) summary
    cd03337
    Location:7 → 524
    TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    TIGR02344
    Location:7 → 528
    chap_CCT_gamma; T-complex protein 1, gamma subunit

  2. NM_001202307.2 → NP_001189236.1  chaperonin containing TCP1 subunit 3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189236.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48605, Q9VER9
    UniProtKB/TrEMBL
    A4V303
    Conserved Domains (2) summary
    cd03337
    Location:7 → 524
    TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    TIGR02344
    Location:7 → 528
    chap_CCT_gamma; T-complex protein 1, gamma subunit

  3. NM_001202308.2 → NP_001189237.1  chaperonin containing TCP1 subunit 3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189237.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48605, Q9VER9
    UniProtKB/TrEMBL
    A4V303
    Conserved Domains (2) summary
    cd03337
    Location:7 → 524
    TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    TIGR02344
    Location:7 → 528
    chap_CCT_gamma; T-complex protein 1, gamma subunit

  4. NM_142315.4 → NP_650572.2  chaperonin containing TCP1 subunit 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650572.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48605, Q9VER9
    UniProtKB/TrEMBL
    A4V303
    Related
    FBpp0082787
    Conserved Domains (2) summary
    cd03337
    Location:7 → 524
    TCP1_gamma; TCP-1 (CTT or eukaryotic type II) chaperonin family, gamma subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
    TIGR02344
    Location:7 → 528
    chap_CCT_gamma; T-complex protein 1, gamma subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V303 A4V303
P48605.2 P48605

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