Asx Additional sex combs [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Asxprovided by FlyBase
Official Full Name: Additional sex combsprovided by FlyBase
Primary source: FLYBASE:FBgn0261823
Locus tag: Dmel_CG8787
See related: AllianceGenome:FB:FBgn0261823
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ASX; CG8787; Dmel\CG8787; FBgn0261823; xen
Summary: Enables chromatin binding activity and deubiquitinase activator activity. Involved in several processes, including imaginal disc-derived appendage morphogenesis; regulation of gene expression; and syncytial blastoderm mitotic cell cycle. Located in chromatin and nucleus. Part of PR-DUB complex. Is expressed in central nervous system; nurse cell; organism; and ventral neurectoderm. Human ortholog(s) of this gene implicated in Bainbridge-Ropers syndrome; SM-AHNMD; and hematologic cancer (multiple). Orthologous to several human genes including ASXL1 (ASXL transcriptional regulator 1) and ASXL2 (ASXL transcriptional regulator 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14503958..14512493)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10391463..10399998)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables deubiquitinase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in antennal development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex comb development	TAS Traceable Author Statement more info	PubMed
involved_in syncytial blastoderm mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PR-DUB complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PR-DUB complex	IDA Inferred from Direct Assay more info	PubMed
part_of PR-DUB complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

Names: Asx-PA; Asx-PB; Asx-PC; Asx-PD; CG8787-PA; CG8787-PB; CG8787-PC; CG8787-PD; additional Sex combs; additional sex comb; additionnal sex comb; xenicid

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The following sections contain reference sequences that belong to a specific genome build. Explain