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Sf3b2 Splicing factor 3b subunit 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33514, updated on 9-Dec-2024

Summary

Official Symbol
Sf3b2provided by FlyBase
Official Full Name
Splicing factor 3b subunit 2provided by FlyBase
Primary source
FLYBASE:FBgn0031493
Locus tag
Dmel_CG3605
See related
AllianceGenome:FB:FBgn0031493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3605; Dmel\CG3605; SF3B2
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; antennal primordium; embryonic/larval midgut primordium; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in Goldenhar syndrome. Orthologous to human SF3B2 (splicing factor 3b subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Sf3b2 in Genome Data Viewer
Location:
23C4-23C4; 2-8 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3026252..3029168, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3026252..3029168, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene alpha1,4-galactosyltransferase 1 Neighboring gene pre-mRNA processing factor 40 Neighboring gene antisense RNA:CR44147 Neighboring gene uncharacterized protein Neighboring gene beta4GalNAcTB pilot Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding  
Component Evidence Code Pubs
part_of U12-type spliceosomal complex  
part_of U2 snRNP  
part_of U2 snRNP PubMed 
part_of U2-type spliceosomal complex  
part_of catalytic step 2 spliceosome PubMed 
part_of catalytic step 2 spliceosome  
located_in nucleus  
part_of precatalytic spliceosome PubMed 
part_of precatalytic spliceosome  

General protein information

Preferred Names
splicing factor 3b subunit 2
Names
CG3605-PA
CG3605-PB
Sf3b2-PA
Sf3b2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    3026252..3029168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273050.1 → NP_001259979.1  splicing factor 3b subunit 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259979.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RC1, Q9VQK7
    Conserved Domains (3) summary
    smart00581
    Location:451 → 508
    PSP; proline-rich domain in spliceosome associated proteins
    COG5182
    Location:166 → 536
    CUS1; Splicing factor 3b, subunit 2 [RNA processing and modification]
    pfam04037
    Location:320 → 446
    DUF382; Domain of unknown function (DUF382)
  2. NM_134895.4 → NP_608739.1  splicing factor 3b subunit 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608739.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RC1, Q9VQK7
    Related
    FBpp0077353
    Conserved Domains (3) summary
    smart00581
    Location:451 → 508
    PSP; proline-rich domain in spliceosome associated proteins
    COG5182
    Location:166 → 536
    CUS1; Splicing factor 3b, subunit 2 [RNA processing and modification]
    pfam04037
    Location:320 → 446
    DUF382; Domain of unknown function (DUF382)
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