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    Ns3 Nucleostemin 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31097, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ns3provided by FlyBase
    Official Full Name
    Nucleostemin 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0266284
    Locus tag
    Dmel_CG14788
    See related
    AllianceGenome:FB:FBgn0266284
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A60; BACN32G11.5; CG14788; Dmel\CG14788; dmNuc3; dNS3; EG:BACN32G11.5; l(1)2Ad; l(1)BA11; l(1)G0431; ns3; NS3
    Summary
    Enables GTPase activity. Involved in regulation of insulin receptor signaling pathway and ribosomal subunit export from nucleus. Located in cytoplasm. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human LSG1 (large 60S subunit nuclear export GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Ns3 in Genome Data Viewer
    Location:
    2A4-2A4; 1-0.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1461844..1464220, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1355877..1358253, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Leucine-rich pentatricopeptide repeat containing 2 Neighboring gene uncharacterized protein Neighboring gene O-fucosyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables GTPase activity  
    Component Evidence Code Pubs
    located_in Cajal body  
    located_in cytoplasm PubMed 
    is_active_in cytosol  
    located_in endoplasmic reticulum  

    General protein information

    Preferred Names
    nucleostemin 3
    Names
    CG14788-PA
    CG14788-PB
    Ns3-PA
    Ns3-PB
    lethal (1) 2Ad
    lethal (1) G0431
    nucleostemin ortholog 3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1461844..1464220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297850.1 → NP_001284779.1  nucleostemin 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284779.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W590
      UniProtKB/TrEMBL
      X2JA43
      Conserved Domains (4) summary
      PHA03395
      Location:270 → 312
      p10; fibrous body protein; Provisional
      cd01857
      Location:164 → 395
      HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:161 → 524
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
      cl21455
      Location:313 → 357
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_130559.3 → NP_569915.1  nucleostemin 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569915.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W590
      UniProtKB/TrEMBL
      X2JA43
      Related
      FBpp0070284
      Conserved Domains (4) summary
      PHA03395
      Location:270 → 312
      p10; fibrous body protein; Provisional
      cd01857
      Location:164 → 395
      HSR1_MMR1; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:161 → 524
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
      cl21455
      Location:313 → 357
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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