U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

kri krishah [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38655, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
kriprovided by FlyBase
Official Full Name
krishahprovided by FlyBase
Primary source
FLYBASE:FBgn0035639
Locus tag
Dmel_CG5537
See related
AllianceGenome:FB:FBgn0035639
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey275; CG5537; Dmel\CG5537; uprt
Summary
Enables uracil phosphoribosyltransferase activity. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; fat body; and larval somatic muscle cell. Orthologous to human UPRT (uracil phosphoribosyltransferase homolog). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See kri in Genome Data Viewer
Location:
64E11-64E11; 3-15 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5810973..5812228)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5804073..5805328)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Tektin C Neighboring gene Ribosomal protein S6 kinase Neighboring gene uncharacterized protein Neighboring gene mad2 Neighboring gene vein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Flies without a spindle checkpoint. Buffin E, et al. Nat Cell Biol, 2007 May. PMID 17417628
  2. The Genetic Basis of Natural Variation in Drosophila melanogaster Immune Defense against Enterococcus faecalis. Chapman JR, et al. Genes (Basel), 2020 Feb 22. PMID 32098395, Free PMC Article
  3. UPRT, a suicide-gene therapy candidate in higher eukaryotes, is required for Drosophila larval growth and normal adult lifespan. Ghosh AC, et al. Sci Rep, 2015 Aug 14. PMID 26271729, Free PMC Article
  4. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. Doumanis J, et al. PLoS One, 2009 Sep 30. PMID 19789644, Free PMC Article
  5. Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation. Sieber MH, et al. Curr Biol, 2015 Apr 20. PMID 25802149, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We find that the Drosophila UPRT homologue, krishah (kri), codes for an enzyme that is required for larval growth, pre-pupal/pupal viability and long-term adult lifespan.
    Title: UPRT, a suicide-gene therapy candidate in higher eukaryotes, is required for Drosophila larval growth and normal adult lifespan.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables uracil phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
krishah
Names
CG5537-PA
CG5537-PB
CG5537-PC
kri-PA
kri-PB
kri-PC
NP_001261451.1
NP_001261452.1
NP_647990.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5810973..5812228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274523.1 → NP_001261452.1  krishah, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261452.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VRQ1
    Conserved Domains (1) summary
    pfam14681
    Location:70 → 260
    UPRTase; Uracil phosphoribosyltransferase

  2. NM_139733.2 → NP_647990.1  krishah, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647990.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VRQ1
    Related
    FBpp0076818, FBtr0077112
    Conserved Domains (1) summary
    pfam14681
    Location:70 → 260
    UPRTase; Uracil phosphoribosyltransferase

  3. NM_001274522.1 → NP_001261451.1  krishah, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261451.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PHI7
    Conserved Domains (1) summary
    pfam14681
    Location:70 → 245
    UPRTase; Uracil phosphoribosyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PHI7 M9PHI7
Q9VRQ1 Q9VRQ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools