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ikb-1 Death domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172817, updated on 9-Dec-2024

Summary

Official Symbol
ikb-1
Official Full Name
Death domain-containing protein
Primary source
WormBase:WBGene00002069
Locus tag
CELE_C04F12.3
See related
AllianceGenome:WB:WBGene00002069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable NF-kappaB binding activity. Involved in defense response to Gram-negative bacterium. Located in cytoplasm. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See ikb-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (9685398..9688653)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Piwi domain-containing protein Neighboring gene tRNA Neighboring gene Large ribosomal subunit protein eL14 Neighboring gene Activin_recp domain-containing protein Neighboring gene pseudo

Interactions

General gene information

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in cytoplasm PubMed 

General protein information

Preferred Names
Death domain-containing protein
NP_492575.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9685398..9688653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060174.6NP_492575.1  Death domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492575.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFS1
    Conserved Domains (4) summary
    cd08310
    Location:515592
    Death_NFkB-like; Death domain of Nuclear Factor-KappaB precursor proteins
    sd00045
    Location:282313
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:153243
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:206399
    Ank_2; Ankyrin repeats (3 copies)
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