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ikb-1 Death domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172817, updated on 9-Dec-2024

Summary

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Official Symbol
ikb-1
Official Full Name
Death domain-containing protein
Primary source
WormBase:WBGene00002069
Locus tag
CELE_C04F12.3
See related
AllianceGenome:WB:WBGene00002069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable NF-kappaB binding activity. Involved in defense response to Gram-negative bacterium. Located in cytoplasm. Human ortholog(s) of this gene implicated in common variable immunodeficiency 10. Orthologous to human NFKB2 (nuclear factor kappa B subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ikb-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
9
Sequence:
Chromosome: I; NC_003279.8 (9685398..9688653)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Piwi domain-containing protein Neighboring gene tRNA Neighboring gene Large ribosomal subunit protein eL14 Neighboring gene Activin_recp domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ancestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development. Brena D, et al. Sci Rep, 2020 Sep 30. PMID 32999373, Free PMC Article
  2. Large-scale genetic screens identify BET-1 as a cytoskeleton regulator promoting actin function and life span. Garcia G, et al. Aging Cell, 2023 Jan. PMID 36404134, Free PMC Article
  3. A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity. Tenor JL, et al. EMBO Rep, 2008 Jan. PMID 17975555, Free PMC Article
  4. A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans. Pujol N, et al. Curr Biol, 2001 Jun 5. PMID 11516642
  5. Dissecting worm immunity. Hodgkin J. Nat Immunol, 2004 May. PMID 15116111

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
Death domain-containing protein
NP_492575.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9685398..9688653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060174.6 → NP_492575.1  Death domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492575.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFS1
    Conserved Domains (4) summary
    cd08310
    Location:515 → 592
    Death_NFkB-like; Death domain of Nuclear Factor-KappaB precursor proteins
    sd00045
    Location:282 → 313
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:153 → 243
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:206 → 399
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein
Heading Accession and Version

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