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nono-1 NOPS domain-containing protein;RRM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 175844, updated on 4-Jan-2025

Summary

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Official Symbol
nono-1
Official Full Name
NOPS domain-containing protein;RRM domain-containing protein
Primary source
WormBase:WBGene00017778
Locus tag
CELE_F25B5.7
See related
AllianceGenome:WB:WBGene00017778
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. Is expressed in body wall musculature and reproductive system. Human ortholog(s) of this gene implicated in cardiomyopathy; intellectual disability; and syndromic X-linked intellectual disability 34. Orthologous to several human genes including PSPC1 (paraspeckle component 1) and SFPQ (splicing factor proline and glutamine rich). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nono-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
7
Sequence:
Chromosome: III; NC_003281.10 (5953557..5958246, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative folylpolyglutamate synthase Neighboring gene 5'-nucleotidase;Putative cytosolic 5'-nucleotidase 3;Transposase Neighboring gene Pseudocleavage protein nop-1 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function. Knott GJ, et al. Protein Sci, 2015 Dec. PMID 26435036, Free PMC Article
  2. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Franz A, et al. Mol Cell, 2011 Oct 7. PMID 21981920, Free PMC Article
  3. Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen. Cui M, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18946043, Free PMC Article
  4. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that the structure of NONO-1 is dimeric and reveal that DBHS domain architecture is consistent within the family from invertebrates to vertebrates.
    Title: Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function.
  2. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication
    Title: CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NOPS domain-containing protein;RRM domain-containing protein
NP_001359971.1
  • Confirmed by transcript evidence
NP_001379859.1
  • Confirmed by transcript evidence
NP_498295.3
  • Confirmed by transcript evidence
NP_871666.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    5953557..5958246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065894.5 → NP_498295.3  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498295.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3GWA1
    Conserved Domains (3) summary
    cd12931
    Location:260 → 349
    eNOPS_SF; NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family
    cd12332
    Location:115 → 184
    RRM1_p54nrb_like; RNA recognition motif 1 in the p54nrb/PSF/PSP1 family
    cd12333
    Location:190 → 269
    RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family

  2. NM_001372604.3 → NP_001359971.1  NOPS domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3GWA0
    Conserved Domains (1) summary
    cl06904
    Location:1 → 69
    eNOPS_SF; NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family

  3. NM_001392114.1 → NP_001379859.1  RRM domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95QI9
    Conserved Domains (2) summary
    PRK10811
    Location:2 → 45
    rne; ribonuclease E; Reviewed
    cl17169
    Location:115 → 157
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_181937.5 → NP_871666.1  RRM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871666.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I7K5
    Conserved Domains (3) summary
    cd12931
    Location:260 → 349
    eNOPS_SF; NOPS domain, including C-terminal helical extension region, in the p54nrb/PSF/PSP1 family
    cd12332
    Location:115 → 184
    RRM1_p54nrb_like; RNA recognition motif 1 in the p54nrb/PSF/PSP1 family
    cd12333
    Location:190 → 269
    RRM2_p54nrb_like; RNA recognition motif 2 in the p54nrb/PSF/PSP1 family
Nucleotide Protein
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